Age-Related Differences of Spectral-Domain Optical Coherence Tomography Data in Koreans

Ji Young Suh; Hong Ryung Seo; Sae Heun Rho

doi:10.3341/jkos.2013.54.2.289

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Suh, Seo, and Rho: Age-Related Differences of Spectral-Domain Optical Coherence Tomography Data in Koreans

Original Article

J Korean Ophthalmol Soc 2007;54(2):289-295.

Published online: 24 August 2007

DOI: https://doi.org/10.3341/jkos.2013.54.2.289

Age-Related Differences of Spectral-Domain Optical Coherence Tomography Data in Koreans

Ji Young Suh, MD, Hong Ryung Seo, MD, Sae Heun Rho, MD, PhD

Department of Ophthalmology, Dong-A University College of Medicine, Busan, Korea

Address reprint requests to Sae Heun Rho, MD, PhD Department of Ophthalmology, Dong-A University Medical Center #26 Daesingongwon-ro, Seo-gu, Busan 602-715, Korea Tel: 82-51-240-5227, Fax: 82-51-254-1987, E-mail: shrho@donga.ac.kr

Received 27 July 201224 October 2012 Accepted 2 January 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

We evaluated the thickness of RNFL and optic nerve head parameters with age in normal eyes using Spectral-Domain Optical Coherence Tomography (SD-OCT).

Methods

A total of 128 normal Korean volunteers in different age groups were recruited (age range, 20-70 years).

Results

A significant negative correlation in average RNFL thickness with increasing age was found. The inferior areas (130.31 ± 3.33 μm) were significantly thicker than other areas (superior area 119.05 ± 2.12 μm, nasal area 71.80 ± 0.57 μm, temporal area 77.72 ± 0.16 μm). The average C/D ratios (mean 0.38 ± 0.14) and vertical C/D ratios (mean 0.35 ± 0.11) both showed significant increases with age, and the vertical C/D ratio correlation coefficient was higher (average C/D ratio r = 0.249, vertical C/D ratio r = 0.537). However, rim area, disc area, and cup volume were not correlated with age.

Conclusions

From these findings, we conclude that, in normal Koreans, the mean RNFL thickness decreases and the C/D ratio increases with age, with the increase in the vertical C/D ratio being greater.

Keywords: Optic disc parameter, Retinal nerve fiber layer thickness, Spectral-domain optical coherence tomography

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Figure 1.

The relationship between average cup/disc (C/D) area ratio and age. Average C/D area ratio increases with age significantly (p < 0.05).

Figure 2.

The relationship between vertical cup/disc (C/D) area ratio and age. Vertical C/D ratio increases with age significantly (p < 0.05).

Table 1.

Demographic data

Age group (year)	No. of subjects (male/female)	Age (years)			Refractive error SE* (Diopter)
Age group (year)	No. of subjects (male/female)	Male	Female	Total	Male	Female	Total
20-29	22 (10/12)	25.10 ± 2.73	26.66 ± 3.07	25.95 ± 2.99	-2.68 ± 3.21	-2.78 ± 1.14	-2.74 ± 1.26
30-39	21 (11/10)	36.63 ± 3.09	36.90 ± 2.73	36.76 ± 2.89	-2.59 ± 3.64	-2.56 ± 2.71	-2.57 ± 2.87
40-49	21 (10/11)	45.30 ± 3.11	47.00 ± 2.35	46.19 ± 2.83	-3.03 ± 3.40	-3.18 ± 2.64	-3.17 ± 2.68
50-59	23 (11/12)	55.09 ± 2.48	54.00 ± 2.91	54.52 ± 2.74	-2.46 ± 1.11	-2.45 ± 1.21	-2.45 ± 1.15
60-69	20 (10/10)	64.80 ± 1.64	64.60 ± 3.21	64.70 ± 2.52	-2.45 ± 1.48	-3.04 ± 3.89	-2.87 ± 1.46
70-79	21 (10/11)	72.80 ± 1.43	74.45 ± 2.40	73.66 ± 2.14	-2.87 ± 1.88	-2.32 ± 1.86	-2.59 ± 1.83
Total	128 (62/66)	49.82 ± 16.34	50.28 ± 16.45	50.06 ± 16.37	-2.68 ± 2.45	-2.71 ± 1.87	-2.70 ± 1.98

Values are presented as mean ± SD.

^* Spherical equivalent.

Table 2.

Correlation of age with RNFL thickness in quadrant scan area

Age (year)	Superior (μm)	T^†	Nasal (μm)	T^†	Inferior (μm)	T^†	Temporal (μm)	T^†	Mean	p-value*
20-29	121.86 ± 1.87	a	71.10 ± 0.39	a	135.02 ± 2.98	a	77.68 ± 0.11	a	103.80 ± 1.45	<0.001
30-39	121.08 ± 2.15	a	70.26 ± 0.58	a	133.45 ± 3.03	a	77.71 ± 0.13	a	103.48 ± 1.77	<0.001
40-49	120.03 ± 2.02	a	71.12 ± 0.61	a	131.01 ± 3.38		77.94 ± 0.17	b	102.57 ± 2.36	<0.001
				b
50-59	118.24 ± 1.98		71.53 ± 0.56	b	129.54 ± 3.45		77.93 ± 0.21	b	100.61 ± 4.72	<0.001
60-69	117.22 ± 2.35		71.09 ± 0.52	b	127.89 ± 3.12		77.55 ± 0.17	b	98.03 ± 2.05	<0.001
70-79	115.88 ± 2.10		70.41 ± 0.60		125.05 ± 3.41		77.52 ± 0,19		96.33 ± 4.79	<0.001
Mean ± SD	119.05 ± 2.12		71.06 ± 0.57		130.32 ± 3.33		77.72 ± 0.16

Values are presented as mean ± SD.

SD = standard deviation.

^* Statistical significances were tested by oneway analysis of variances among groups

^† The same letters indicate non-significant difference between groups based on duncan's multiple comparison test.

Table 3.

Correlation of age with RNFL thickness in clock hour scan area

Age (year)	Superior						Nasal						Inferior						Temporal						p-value*
Age (year)	Area 12 (μm)	T^†	Area 1 (μm)	T^†	Area 2 (μm)	T^†	Area 3 (μm)	T^†	Area 4 (μm)	T^†	Area 5 (μm)	T^†	Area 6 (μm)	T^†	Area 7 (μm)	T^†	Area 8 (μm)	T^†	Area 9 (μm)	T^†	Area 10 (μm)	T^†	Area 11 (μm)	T^†
20-29	130.7	a	121.1	a	96.9 ±	a	70.1 ±	a	74.4 ±	a	103.9 ±	a	141.2	a	141.8		84.9 ±	a	52.4 ±	a	95.6 ±	a	143.8	a	<0.001
20-29	± 3.1		± 2.9		1.1		0.9		0.7		2.4		± 3.1		± 3.9		0.2		0.2		0.7		± 3.9
30-39	127.1	a	119.8	a	95.1 ±	a	64.5 ±	a	76.1 ±	a	99.8 ±	a	138.3	a	137.4		83.5 ±	a	54.6 ±	a	93.2 ±	a	142.7	a	<0.001
30-39	± 2.9		± 3.1	b	1.2		0.3		0.5		1.9		± 3.7		± 3.4		0.4		0.2	b	0.6		± 4.2	b
40-49	127.1	a	118.2	b	94.4 ±	a	66.5 ±	a	73.4 ±	a	103.2 ±	b	135.7		133.1		79.6 ±		56.8 ±	b	90.4 ±	b	135.4	b	<0.001
40-49	± 3.2		± 3.0		1.0		0.5		0.4		2.3		± 3.5		± 3.1		0.5		0.3		0.7		± 4.1
50-59	124.2		116.3		91.3 ±		65.7 ±	b	71.5 ±	b	101.2 ±	b	136.6		134.1		81.1 ±		52.4 ±	b	95.1 ±	b	137.5		<0.001
50-59	± 2.7		± 3.4		1.3		0.4		0.3		2.5		± 2.9		± 3.3		0.3		0.4		1.0		± 3.6
60-69	122.4		117.1		88.3 ±		63.8 ±	b	69.7 ±	b	92.7 ±		134.5		132.7		77.7 ±		48.6 ±	b	91.8 ±	c	138.5		<0.001
60-69	± 3.2		± 3.6		1.0		0.7	c	0.6		2.0		± 3.0		± 2.9		0.4		0.2		0.9		± 3.8
70-79	119.5		111.7		86.3 ±		60.4 ±	c	63.5 ±		96.4 ±		131.5		129.4		75.3 ±		53.4 ±		88.2 ±	c	133.1		<0.001
70-79	± 2.6		± 2.8		0.9		0.6		0.9		1.8		± 3.2		± 3.1		0.3		0.3		0.8		± 3.6
Mean	125.1		117.3		92.0 ±		65.1 ±		71.4 ±		99.5 ±		136.3		134.7		80.3 ±		53.0 ±		92.4 ±		138.5
± SD	± 3.9		± 3.2		4.1		3.2		4.4		4.3		± 3.30		± 4.3		4.9		2.7		2.9		± 4.13

Values are presented as mean ± SD.

SD = standard deviation.

^* Statistical significances were tested by oneway analysis of variances among quadrant groups

^† The same letters indicate non-significant difference between groups based on duncan's multiple comparison test.

Table 4.

Correlation of age with Optic disc head parameters

Age (year)	Rim area (mm²)	Disc area (mm²)	Cup volume (mm³)	Average C/D ratio*	Vertical C/D ratio*
20-29	1.47 ± 0.18	1.70 ± 0.27	0.04 ± 0.009	0.29 ± 0.09	0.26 ± 0.07
30-39	1.48 ± 0.25	1.78 ± 0.29	0.05 ± 0.010	0.37 ± 0.11	0.28 ± 0.09
40-49	1.45 ± 0.24	1.79 ± 0.32	0.06 ± 0.011	0.39 ± 0.15	0.33 ± 0.10
50-59	1.43 ± 0.20	1.83 ± 0.34	0.06 ± 0.013	0.40 ± 0.16	0.37 ± 0.12
60-69	1.41 ± 0.22	1.73 ± 0.30	0.07 ± 0.012	0.42 ± 0.15	0.41 ± 0.14
70-79	1.45 ± 0.26	1.74 ± 0.31	0.04 ± 0.008	0.43 ± 0.14	0.44 ± 0.13
Mean ± SD	1.45 ± 0.22	1.76 ± 0.31	0.05 ± 0.01	0.38 ± 0.14	0.35 ± 0.11
p-value^†	0.371	0.156	0.083	<0.01	<0.01

Values are presented as mean ± SD.

^* Average C/D ratio and vertical C/D ratio were compared by paired t-test and showed statistical difference (p < 0.001)

^† Statistical significances were tested by one-way analysis of variances among age groups.

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