Analysis of Eye Drops Applying Behavior in Glaucoma Patients

Min A Lee; Jung I1 Moon; Myoung Hee Park

doi:10.3341/jkos.2013.54.10.1561

Journal List > J Korean Ophthalmol Soc > v.54(10) > 1009508

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Lee, Moon, and Park: Analysis of Eye Drops Applying Behavior in Glaucoma Patients

Original Article

J Korean Ophthalmol Soc 2013;54(10):1561-1566.

Published online: 3 September 2013

DOI: https://doi.org/10.3341/jkos.2013.54.10.1561

Analysis of Eye Drops Applying Behavior in Glaucoma Patients

Min A Lee, MD, Jung I1 Moon, MD, PhD, Myoung Hee Park, MD, PhD

Department of Ophthalmology and Visual Science, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea

Address reprint requests to Myoung Hee Park, MD, PhD, Department of Ophthalmology, The Catholic University of Korea, Yeouido St. Mary's Hospital, #10 63-ro, Yeongdeungpo-gu, Seoul 150-713, Korea, Tel: 82-2-3779-1243, Fax: 82-2-3775-1245, E-mail: marypark@catholic.ac.kr

Received 4 March 2013 Revised 15 May 2013 Accepted 5 August 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study was conducted to understand the eye drop application method in patients with glaucoma.

Methods

A survey was performed in 5 hospitals on patients diagnosed with glaucoma using eye drops for more than 1 month. Variables associated with eye drop application such as pressing on a dacryocyst after application, time interval between multiple eye drop medications, hygienic management of an eye dropper and shaking a bottle of eye drops before use were evaluated.

Results

A total of 581 patients were surveyed in the present study. Regarding pressing on a dacryocyst after applying eye drops, 58 (10%) patients responded always, 103 patients (18%) sometimes, and 409 patients (70%) never. Three hundred fifteen patients (54%) did not touch the eye dropper to their eyes, 190 patients (33%) always shook the eye drop bottle before use and 106 patients (18%) shook the bottle sometimes.

Conclusions

When using eye drops for glaucoma to reduce the intraocular pressure, most patients are committing errors, reducing the effect of treatment and likely causing side effects. When prescribing eye drops to glaucoma patients, the physician should educate patients on the proper method of application.

Keywords: Glaucoma, Noncompliance, Topical antiglaucoma medication

References

1. Kass MA, Heuer DK, Higginbotham EJ. . The ocular hypertension treatment study: A randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002; 120:701–13. discussion 829-30.

2. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. collaborative normal-tension glaucoma study group. Am J Ophthalmol. 1998; 126:498–505.

3. Patel SC, Spaeth GL. Compliance in patients prescribed eyedrops for glaucoma. Ophthalmic Surg. 1995; 26:233–6.

4. Chang JS Jr, Lee DA, Petursson G. . The effect of a glaucoma medication reminder cap on patient compliance and intraocular pressure. J Ocul Pharmacol. 1991; 7:117–24.

5. Ashburn FS Jr, Goldberg I, Kass MA. Compliance with ocular therapy. Surv Ophthalmol. 1980; 24:237–48.

6. Ritun R, Shield M, Krupin T. The glaucomas. 1996.

7. Simel DL, Simel PJ. Does lacrimal duct occlusion decrease intraocular pressure in patients refractory to medical treatment for glaucoma? A randomized, sham-controlled, crossover trial. J Clin Epidemiol. 1988; 41:859–65.

8. Fraunfelder FT. Extraocular fluid dynamics: How best to apply topical ocular medication. Trans Am Ophthalmol Soc. 1976; 74:457–87.

9. Ellis PP, Wu PY, Pfoff DS. . Effect of nasolacrimal occlusion on timolol concentrations in the aqueous humor of the human eye. J Pharm Sci. 1992; 81:219–20.

10. Zimmerman TJ, Kooner KS, Kandarakis AS, Ziegler LP. Improving the therapeutic index of topically applied ocular drugs. Arch Ophthalmol. 1984; 102:551–3.

11. Foster PJ, Buhrmann R, Quigley HA, Johnson GJ. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002; 86:238–42.

12. Ahn DH, Lee YG, Hong YJ. Factors affecting compliance with prescribed eyedrops for glaucoma. J Korean Ophthalmol Soc. 1998; 39:2145–51.

13. Chung PH, Chin TF, Lach JL. Kinetics of the hydrolysis of pilocarpine in aqueous solution. J Pharm Sci. 1970; 59:1300–6.

14. Kass MA, Hodapp E, Gordon M. . Patient administration of eyedrops: Observation. part II. Ann Ophthalmol. 1982; 14:889–93.

15. Kholdebarin R, Campbell RJ, Jin YP, Buys YM. Multicenter study of compliance and drop administration in glaucoma. Can J Ophthalmol. 2008; 43:454–61.

16. Zimmerman TJ, Diestelhorst M, Suverkrup R. Practical aspects of controlling glaucoma medically or how to make your glaucoma medicines work for you. glaucoma editorial. Klin Monbl Augenheilkd. 1980; 209:717–28.

17. Mishima S, Gasset A, Klyce SD Jr, Baum JL. Determination of tear volume and tear flow. Invest Ophthalmol. 1966; 5:264–76.

18. R RA.Shields textbook of glaucoma. 2011.

19. Nourry H, Viard C, Cambourieu C, Warnet JM. A relevant choice for corticoid eye drops: Solution or suspension? J Fr Ophtalmol. 2011; 34:691–6.

20. Kwon KA, Diestelhorst M. Süverkrüp R. Dosage problems in suspension eyedrops. Klin Monbl Augenheilkd. 1996; 209(2-3):144–9.

Figure 1.

Proportion of sensation of instillation.

Figure 2.

Proportion of punctal compression.

Figure 3.

Proportion of frequency of bottle tip touching.

Figure 4.

Proportion of interval between eyedrops use.

Figure 5.

Proportion of frequency shake bottle before use.

Table 1.

List of hospitals and principal investigators involved in this study (Korean Glaucoma Compliance Study Group)

	Hospital	Location	Level of refer	PI
A	Yeouido St. Mary's Hospital	Seoul	3’	JI Moon
B	Kangnam St. Mary's Hospital	Seoul	3’	CK Park
C	Uijeongbu St. Mary's Hospital	Gyeonggi-do	2’	SY Kim
D	Incheon St. Mary's Hospital	Incheon	2’	NY Lee
E	Kim's Eye Hospital	Seoul	2’	YH Sohn

Table 2.

Qustionnaires about how to use the eyedrops

Do you have a sensation of instillation when you apply eyedrop?	□Always	□Sometimes	□ No
Do you press the punctum for 1-2 minuts afer applying eyedrop?	□Always	□Sometimes	□ No
Do you touch the eye droppler to your eye when you apply eyedrop?	□Always	□Sometimes	□ No
How do you apply interval between euedrop use when you apply different kinds of eyedrop?	□1 minutes	□5 minutes	□ 10 minutes
Do you shake bottle before use?	□Always	□Sometimes	□No

TOOLS

Similar articles