Journal List > J Korean Ophthalmol Soc > v.54(9) > 1009487

Yang, Kim, Kim, Wee, and Oh: Clinicopathological Report of Squamous Cell Carcinoma of Conjunctiva and Cornea in a Patient with AIDS

Abstract

Purpose

To describe the clinical and histopathological findings of corneal and conjunctival squamous cell carcinoma (SCC) in a patient with acquired immune deficiency syndrome (AIDS).

Case summary

A 45-year-old Korean male who had been diagnosed of AIDS 20 years before presented with vascularized mass in the inferotemporal conjunctiva and in the cornea. The patient underwent an en bloc excisional biopsy of the mass, application of mitomycin C, and repeated cycles of freeze-thaw. Histopathology revealed dysplastic squamous epithelium in the full thickness of epithelial layer. Immunohistochemical staining for proliferation markers showed that the tumor had a high proliferation index: Ki-67 was positive throughout the full epithelial layer, and both p53 and p16 were positive. The patient had an adjuvant chemotherapy with topical interferon alpha 2b (IFNα 2b) for 8 months after surgery.

Conclusions

Given the high proliferation index of the tumor in this patient, close observation and combined adjuvant che-motherapy will be required to prevent recurrence in a patient with AIDS.

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Figure 1.
(A-C) Anterior segment photography showed semitranslucent hypervascular mass with irregular surface involving in-ferotemporal conjunctiva and cornea. (D) Anterior segment optical coherence tomography showed flat elevated lesion with 0.29 mm thickness.
jkos-54-1440f1.tif
Figure 2.
(A) Hematoxylin & eosin staining showed squamous carci-noma in situ with koilocytotic atypia. (B) Immunohistochemical staining for Ki-67 showed that Ki-67 was positive throughout the full epithelial layer in 60% of the epithelium. (C) Immunohisto- chemical staining for p16 revealed positive in 70% of the epithelium. Original magnification ×100.
jkos-54-1440f2.tif
Figure 3.
Anterior segment photography at 8 months after excision: Partial limbal insufficiency at the excision site was observed without recurrence of the tumor.
jkos-54-1440f3.tif
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