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Abstract
Purpose
To study the clinical features, pathophysiologic and radiologic characteristics, and prognostic factors in patients with orbital and adnexal lymphoma.
Methods
The medical records of patients who were diagnosed with orbital and adnexal lymphoma, and patients who were treated and observed, were retrospectively reviewed. Information regarding age, sex, initial symptoms and signs when visiting the hospital, mass location and features, histology and staging, response to treatment and side effects, and prognosis were collected.
Results
Fifty-four patients, with an equal number of men and women, were diagnosed with orbital and adnexal lymphoma. The average age was 50.9 years (14 to 82 years). The main symptom was orbital swelling, and the main site was conjunctiva. Histologically, Mucosa-Associated Lymphoid Tissue (MALT) lymphoma was the most observed. The major ocular complication was dry eye syndrome, which showed good response with ophthalmic treatment. Radiologic features did not have prognostic relevance.
Conclusions
Most orbital and adnexal lymphomas were MALT lymphomas. Proper therapy according to stage can result in a good response and remission. In the present study, the therapy complications were well-controlled with medical treatment, and radiologic features of a mass could not be considered as a prognostic factor.
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Table 1.
Presenting symptoms in patients with orbital lymphoma (multiple)
| Symptoms | No. of patients (%) |
|---|---|
| Eyelid swelling | 26 (38.2) |
| Palpable mass | 15 (22.1) |
| Proptosis | 10 (14.7) |
| Diplopia | 2 (2.9) |
| Foreign body sensation | 8 (11.8) |
| Injection | 3 (4.4) |
| Asymptomatic | 4 (5.9) |
Table 2.
Location in patients with orbital lymphoma (multiple)
| Localization | No. of patients (%) |
|---|---|
| Conjunctiva | 21 (35) |
| Lacrimal gland | 9 (15) |
| Lacrimal sac or nasolacrimal duct | 3 (5) |
| Eyelid | 7 (11.7) |
| Other orbital cavity | 20 (33.3) |
Table 3.
Histopathological classification in patients with orbital lymphoma (WHO classification)
Table 4.
Clinical staging in patients with orbital lymphoma (Ann Arbor classification)
| Stage | No. of patients (%) |
|---|---|
| I | 23 (60.5) |
| II | 12 (31.6) |
| III | 1 (2.6) |
| IV | 2 (5.3) |
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