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Abstract
Case summary
A 72-year-old male patient presented with swelling and erythema on the upper and lower eyelid of 10 months in duration. After the diagnosis of cutaneous angiosarcoma via tissue biopsy, no evidence of systemic metastasis was found. The right eyelid was treated with radiation therapy and a partial clinical response was achieved. After 4 months of follow-up, swelling and a red-purple plaque developed on the same (right) eyelid. Another biopsy was performed and the histological examination indicated a recurrence of angiosarcoma. Neither local nor distant metastases were observed. However, large-sized and ill-defined margins warranted size reduction by paclitaxel neoadjuvant chemotherapy, followed by surgical excision and eyelid reconstruction.
References
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Figure 1.
(A) This photograph shows erythematous swelling on the right upper and lower eyelid. (B) At 4 months after radiation therapy, newly developed angiosarcoma of his right upper eyelid is observed.
Figure 2.
(A) Irregular vascular proliferation is shown in subepithelial area of the specimen obtained from the patient (H&E, ×100).(B) Cytological atypia is seen under high power (H&E, ×400). (C, D) Atypical endothelial cells shows immunostain for CD31 (C: ×400) and CD32 (D: ×400).
Figure 3.
(A) The lesion of angiosarcoma was removed widely, including surrounding normal skin and connective tissue. During the surgery, the tumor was completely removed by performing frozen section biopsy of the lesion and its surrounding area under the local anesthesia. (B) Skin graft using the left upper eyelid was performed.
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