Journal List > J Korean Ophthalmol Soc > v.54(7) > 1009430

J Korean Ophthalmol Soc. 2013 Jul;54(7):1114-1118. Korean.
Published online July 15, 2013.
Copyright © 2013 The Korean Ophthalmological Society
A Case of Angiosarcoma Arising from the Eyelid
Ga Young Yoo, MD, Su Kyung Jung, MD, Ji Sun Paik, MD and Suk Woo Yang, MD, PhD
Department of Ophthalmology and Visual Science, The Catholic University of Korea College of Medicine, Seoul, Korea.

Address reprint requests to Suk Woo Yang, MD, PhD. Department of Ophthalmology, The Catholic University of Korea, Seoul St. Mary's Hospital, #222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea. Tel: 82-2-2258-1200, Fax: 82-2-599-7405, Email:
Received December 29, 2012; Revised February 22, 2013; Accepted May 08, 2013.



To report a case of angiosarcoma arising from the eyelid.

Case summary

A 72-year-old male patient presented with swelling and erythema on the upper and lower eyelid of 10 months in duration. After the diagnosis of cutaneous angiosarcoma via tissue biopsy, no evidence of systemic metastasis was found. The right eyelid was treated with radiation therapy and a partial clinical response was achieved. After 4 months of follow-up, swelling and a red-purple plaque developed on the same (right) eyelid. Another biopsy was performed and the histological examination indicated a recurrence of angiosarcoma. Neither local nor distant metastases were observed. However, large-sized and ill-defined margins warranted size reduction by paclitaxel neoadjuvant chemotherapy, followed by surgical excision and eyelid reconstruction.


Angiosarcoma commonly occurs on the face and scalp, but rarely occurs on the eyelids. Herein, the authors report a case of angiosarcoma arising from the eyelid.

Keywords: Angiosarcoma; Eyelid; Recurrent angiosarcoma


Figure 1
(A) This photograph shows erythematous swelling on the right upper and lower eyelid. (B) At 4 months after radiation therapy, newly developed angiosarcoma of his right upper eyelid is observed.
Click for larger image

Figure 2
(A) Irregular vascular proliferation is shown in subepithelial area of the specimen obtained from the patient (H&E, ×100). (B) Cytological atypia is seen under high power (H&E, ×400). (C, D) Atypical endothelial cells shows immunostain for CD31 (C: ×400) and CD32 (D: ×400).
Click for larger image

Figure 3
(A) The lesion of angiosarcoma was removed widely, including surrounding normal skin and connective tissue. During the surgery, the tumor was completely removed by performing frozen section biopsy of the lesion and its surrounding area under the local anesthesia. (B) Skin graft using the left upper eyelid was performed.
Click for larger image

Figure 4
After 6 months, a postoperative photograph shows healthy grafted skin and no recurrence of the tumor in the right upper eyelid.
Click for larger image

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