Primary Orbital MALT Lymphoma Associated with Localized Amyloidosis

Jeong Lyu In; In Woo Kyung; Kim Yoon-Duck

doi:10.3341/jkos.2013.54.7.1109

Journal List > J Korean Ophthalmol Soc > v.54(7) > 1009429

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In, Kyung, and Yoon-Duck: Primary Orbital MALT Lymphoma Associated with Localized Amyloidosis

Original Article

J Korean Ophthalmol Soc 2013;54(7):1109-1113.

Published online: 7 September 2013

DOI: https://doi.org/10.3341/jkos.2013.54.7.1109

Primary Orbital MALT Lymphoma Associated with Localized Amyloidosis

Jeong Lyu In, MD, In Woo Kyung, MD, PhD, Kim Yoon-Duck, MD, PhD

¹Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Address reprint requests to Yoon-Duck Kim, MD, PhD Department of Ophthalmology, Samsung Medical Center,#81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea Tel: 82-2-3410-3561, Fax: 82-2-3410-0074 E-mail: ydkimoph@skku.edu

* This study was presented as a poster at the 105th Annual Meeting of the Korean Ophthalmology Society 2011.

Received 11 January 201318 February 2013 Accepted 6 May 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report a case of primary orbital MALT lymphoma with localized amyloidosis.

Case summary

A 61-year-old male visited our clinic with diplopia, which had developed approximately 5 months earlier. Magnetic resonance imaging of the orbit showed an ill-defined well-enhanced mass in the left inferior orbit. Incisional biop-sy of the orbital mass was performed. Histopathological examination revealed diffuse deposits of an amorphous, eosino-philic substance in the extracellular matrix and vessels with lymphocytes infiltration. Lymphocytes were positive for the im-munohistochemical stain against the CD20 and κ-light chain antigens. The amorphous material stained positive for κ-light chain antigen, and Congo red staining showed birefringence.

Conclusions

We report a rare case of primary orbital MALT lymphoma associated with localized amyloidosis.

Keywords: Amyloidosis, MALT lymphoma

References

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Figure 1.

Clinical photograph showing proptosis of the left eye.

Figure 2.

(A) T1-weighted precontrast axial image demonstrating an ill-defined mass in the left orbit isointense to extraocular muscle. (B) T2-weighted precontrast coronal image showing a mass with subtle high signal intensity in the left inferior orbit. (C) T1-weighted postcontrast image demonstrates a well-enhancing soft tissue mass.

Figure 3.

Axial nonenhanced CT scan reveals left inferior or-bital soft tissue mass with calcifications.

Figure 4.

(A) Histopathologic examination reveals diffuse deposits of an amorphous, eosinophilic substance in the extracellular ma-trix and vessels with lymphocytes infiltration (hematoxylin and eosin, ×200). (B) High-power magnification shows that the cells are predominantly small lymphocytes (hematoxylin and eosin, ×400). (C) Lymphocytes stain positive for the immunohistochemical stain against the CD20 antigen (×400). (D) Lymphocytes and an amorphous material stain positive for the immunohistochemical stain against κ-light chain antigen (×100). (E) The amorphous material stains positive with Congo red and F, demonstrates ap-ple-green birefringence under the polarized light (Congo red, ×100).

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