Central Corneal Thickness and Corneal Endothelial Cells in Pseudoexfoliation Syndrome

Boem Chang In; Won Paik Dong; Jin Kim Tai; Shin Ha Hyo; Hyun Park Jung

doi:10.3341/jkos.2013.54.7.1060

Journal List > J Korean Ophthalmol Soc > v.54(7) > 1009421

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In, Dong, Tai, Hyo, and Jung: Central Corneal Thickness and Corneal Endothelial Cells in Pseudoexfoliation Syndrome

Original Article

J Korean Ophthalmol Soc 2013;54(7):1060-1065.

Published online: 7 September 2013

DOI: https://doi.org/10.3341/jkos.2013.54.7.1060

Central Corneal Thickness and Corneal Endothelial Cells in Pseudoexfoliation Syndrome

Boem Chang In, MD¹, Won Paik Dong, MD², Jin Kim Tai, MD¹, Shin Ha Hyo, MD¹, Hyun Park Jung, MD¹

¹Department of Ophthalmology, Seoul Paik Hospital, Inje University College of Medicine¹, Seoul, Korea

²Department of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine², Seoul, Korea

Address reprint requests to Jung Hyun Park, MD Department of Ophthalmology, Inje University Seoul Paik Hospital, #9 Mareunnae-ro, Jung-gu, Seoul 100-032, Korea Tel: 82-2-2270-0082, Fax: 82-2-2266-6159 E-mail: hyuny@medimail.co.kr

* This study was presented as a poster at the 108th Annual Meeting of the Korean Ophthalmology Society 2012.* This study was supported by a Grant of Inje University, 2010.

Received 22 September 201225 January 2013 Accepted 13 April 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate the central corneal thickness (CCT) and corneal endothelial cell density (ENDO) in pseudoexfolia-tion syndrome.

Methods

Medical records of patients who underwent a preoperative examination for cataract surgery and an examination for glaucoma were retrospectively reviewed. The present study included 44 patients (59 eyes) and age- and sex-matched controls. The total pseudoexfoliation patients divided into 2 groups, such as pseudoexfoliation syndrome (28 eyes) and pseudoexfoliative glaucoma (21 eyes) .The intraocular pressure (IOP), CCT, ENDO, corneal curvature (CC) and axial length (AL) were measured.

Results

The total pseudoexfoliation group showed significantly higher IOP ( p = 0.001), thinner CCT ( p = 0.003) and lower ENDO ( p = 0.037). The pseudoexfoliation syndrome group showed significantly thinner CCT ( p = 0.010) and lower EDNO ( p = 0.041), but no significant difference in IOP ( p = 0.941). There was no significant difference in CCT ( p = 0.060) and ENDO ( p = 0.171) between the pseudoexfoliative glaucoma group and controls, but the pseudoexfolliative glaucoma group showed significantly higher IOP ( p < 0.001).

Conclusions

The pseudoexfoliation group showed thinner CCT which should be taken into consideration when evaluating IOP with the applanation tonometer and diagnosing glaucoma, especially in pseudoexfoliation syndrome patients.

Keywords: Central corneal thickness, Corneal curvature, Corneal endothelial cell density, Pseudoexfoliation syndrome

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Table 1.

Demographic and general medical conditions of the patients and controls

	Total pseudoexfoliation	Control
Age (year)	68.75 ± 8.85	68.75 ± 8.95
Range	48-84	47-85
Sex
Male	22	22
Female	22	22
Systemic disorder^*
DM	20 (25)	20 (25)
HTN	28 (37)	28 (37)
None	7 (10)	7 (10)

Values are presented as mean ± SD. DM = diabetes mellitus; HTN = hypertension.

^* Persons (eyes).

Table 2.

Central corneal thickness, intraocular pressure, corneal endothelial cell density, corneal curvature, axial length values in Control and Study Eyes

	Control (n = 59)	Total pseudoexfoliation (n = 59)	p-value	Pseudoexfoliation syndrome (n = 28)	p-value	Pseudoexfoliative glaucoma (n = 31)	p-value
CCT (μ m)	548 ± 25.29	533.34 ± 27.84	0.003^*	521.00 ± 35.74	0.010^*	538.42 ± 17.06	0.060
ENDO (/mm²)	2660.80 ± 339.73	2513.02 ± 417.78	0.037^*	2505.36 ± 298.51	0.041^*	2519.94 ± 507.09	0.171
IOP (mm Hg)	13.80 ± 3.50	16.73 ± 4.85	0.001^*	13.87 ± 3.35	0.941	19.00 ± 4.68 <	<0.001^*
CC (D)
K horizontal	44.32 ± 1.59	44.20 ± 1.18	0.647	44.31 ± 1.26	0.968	44.11 ± 1.12	0.463
K vertical	44.47 ± 1.84	44.11 ± 1.44	0.236	44.30 ± 1.71	0.676	43.94 ± 1.14	0.095
AL (mm)	23.43 ± 1.18	23.33 ± 1.27	0.646	23.14 ± 1.02	0.250	23.49 ± 1.46	0.842

Values are presented as mean ± SD. CCT = central corneal thickness; IOP = intraocular pressure; ENDO = corneal endothelial cell density; CC = corneal curvature; D = diopter; AL = axial length.

^* Comparison with control eyes by independent t-test, p < 0.05.

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