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Choi, Lee, Ahn, Cho, and You: Cultured Organisms and Antibiotic Susceptibility in Infectious Ocular Disease: Results Over a Ten-Year Period
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(7): 934-940.

Published online: 13 July 2012

DOI: https://doi.org/10.3341/jkos.2012.53.7.934

Cultured Organisms and Antibiotic Susceptibility in Infectious Ocular Disease: Results Over a Ten-Year Period

Hyun Tae Choi, MD, Dong-Wook Lee, MD, Min Ahn, MD, Nam Chun Cho, MD, In Cheon You, MD

Department of Ophthalmology, Chonbuk National University Hospital and Medical School, Research Institute of Clinical Medicine, Jeonju, Korea.

Address reprint requests to In Cheon You, MD. Department of Ophthalmology, Chonbuk National University Hospital, #20 Geonji-ro, Deokjin-gu, Jeonju 561-721, Korea. Tel: 82-63-250-2581, Fax: 82-63-250-1960, you2ic@paran.com

Received 10 October 2011       Accepted 24 April 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To investigate the ocular regional incidence, causative species and antibiotic susceptibility in patients with infectious ocular disease whose causative organism was isolated.

Methods

A total of 519 eyes in 519 patients with infectious ocular disease, who were diagnosed by smears and cultures from January 2000 to December 2009 were retrospectively reviewed.

Results

The mean age of the 519 patients was 54.0 years, and 66.1% of the patients were male. The most common systemic disease was diabetes mellitus. The most common previous ocular disease was keratoconjunctivitis. Specimens were most frequently swabbed from the cornea, where 81.2% were bacteria isolates and 18.8% fungi isolates. The most prevalent causative organism was Staphylococcus epidermidis, and the most prevalent fungus was Fusarium species. Vancomycin, ceftazidime, and fourth-generation fluoroquinolone maintained high antibiotic susceptibility. Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis were increasing near the end of the reference period, and endophthalmitis was more common in methicillin-resistant Staphylococcus.

Conclusions

Identifying the causative organism in infectious ocular disease by smears and cultures is essential. More effective treatment of infectious ocular disease would be possible by analyzing the frequent organism, clinical manifestations, and antibiotic susceptibility. More caution is necessary due to the increase in methicillin-resistant Staphylococcus.

Keywords: Antibiotic susceptibility, Cultured organisms, Infectious ocular disease, Methicillin-resistant Staphylococcus

Figures and Tables

Figure 1
Percent of patients with MRSA by 2-year interval. The year-long intervals start January 1 and December 31 of the following year. MRSA = Methicillin-resistant Staphlyococcus aureus.
jkos-53-934-g001
Figure 2
Percent of patients with MRSE by 2-year interval. The year-long intervals start January 1 and December 31 of the following year. MRSE = Methicillin-resistant Staphlyococcus epidermidis.
jkos-53-934-g002
Table 1
Prevalence of the micro-organisms isolated from ocular infectious disease
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Table 2
Antibiotic susceptibility of Gram-positive bacteria
jkos-53-934-i002

Values are presented as n (%).

Antibiotics susceptibility = susceptible organisms / total isolated organisms, for each antibiotic (%).

Table 3
Antibiotic susceptibility of Gram-negative bacteria
jkos-53-934-i003

Values are presented as n (%).

Antibiotics susceptibility = susceptible organisms / total isolated organisms, for each antibiotic (%).

Table 4
MRSA and MSSA proportion in ocular infectious disease
jkos-53-934-i004

Values are presented as n (%).

MRSA = Methicillin-resistant Staphlyococcus aureus; MSSA = Methicillin-susceptible Staphylococcus aureus.

Table 5
MRSE and MSSE proportion in ocular infectious disease
jkos-53-934-i005

Values are presented as n (%).

MRSE = Methicillin-resistant Staphlyococcus epidermidis; MSSE = Methicillin-susceptible Staphylococcus epidermidis.

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