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Han, Suh, Lim, and Kee: The Relations Between Progression of Peripapillary Chorioretinal Atrophy and Progression of Normal Tension Glaucoma
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(6): 807-812.

Published online: 16 June 2012

DOI: https://doi.org/10.3341/jkos.2012.53.6.807

The Relations Between Progression of Peripapillary Chorioretinal Atrophy and Progression of Normal Tension Glaucoma

Jong Chul Han, MD, Wool Suh, MD, Dong Hui Lim, MD, Changwon Kee, MD, PhD

Department of Ophthalmology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.

Address reprint requests to Changwon Kee, MD, PhD. Department of Ophthalmology, Samsung Medical Center, #81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. Tel: 82-2-3410-3564, Fax: 82-2-3410-0074, cwkee@smc.samsung.co.kr

Received 4 August 2011       Accepted 4 May 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To evaluate the relations between progression of glaucoma in visual field and peripapillary area change in normal tension glaucoma (NTG).

Methods

We respectively evaluated 66 patients (66 eyes) with normal tension glaucoma; these patients were classified as progressive glaucoma group and non-progressive glaucoma group by visual field test. Interobserver and intraobserver agreement was evaluated for qualitative assessment. Zone β change was measured by Image J (National Institute of Health, Bethesda, USA) by two methods. One method used paired t-test and the other method used CV (correlation of variation) to define significant progression of zone β.

Results

46 patients (46 eyes) were classified as progressive glaucoma and 20 patients (20 eyes) were classified as non-progressive glaucoma. There was no statistically significant different change of zone β between two groups and there were no changes of zone β over coefficient of variation (CV).

Conclusions

The measurement of change of zone β seems to be of no use in recognition of progression in normal tension glaucoma.

Keywords: Normal tension glaucoma, Peripapillary atrophy, Progressive glaucoma, Progressive peripapillary atrophy, Zone β

Figures and Tables

Figure 1
Scatterplots showing the interobserver agreement between the two observers in measuring areas (pixel) of progression of peripapillary atrophy (beta zone).
jkos-53-807-g001
Figure 2
Scatterplots showing the intraobserver agreement between each observation in measuring areas (log pixel) of progression of peripapillary atrophy (beta zone).
jkos-53-807-g002
Figure 3
Distribution of coefficient of variation for progression of beta zone.
jkos-53-807-g003
Table 1
Demographic characteristics of the studied population
jkos-53-807-i001

Values are given as number or mean ± SD.

*Glaucomatic progression in Humphrey visual field; †Chi-square test; ‡Independent t-test.

Table 2
Change of visual field indices in progressive group and non progressive group
jkos-53-807-i002

Values are given as mean ± SD.

MD = mean deviation; PSD = pattern standard deviation.

*p-value calculated by paired t-test.

Table 3
Incidence of zone β progression by using method 1
jkos-53-807-i003

Values are given as number (%).

*Significant zone β progression between baseline and last follow-up was measured by paired t-test.

Table 4
Incidence of zone β progression by using method 2
jkos-53-807-i004

Values are given as number (%).

*Zone β change over maximum CV (coefficient of variation) between baseline and last follow-up was regarded as significant progression.

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