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Lee: Analysis of Factors Associated with Variability in Measures Obtained by Spectral Domain Optical Coherence Tomography
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(5): 639-646.

Published online: 16 May 2012

DOI: https://doi.org/10.3341/jkos.2012.53.5.639

Analysis of Factors Associated with Variability in Measures Obtained by Spectral Domain Optical Coherence Tomography

Yong Jun Lee, MD

Department of Ophthalmology, Sorokdo National Hospital, Goheung, Korea.

Address reprint requests to Yong Jun Lee, MD. Department of Ophthalmology, Sorokdo National Hospital #65 Sorokhaean-gil, Doyang-eup, Goheung 548-904, Korea. Tel: 82-61-840-0623, Fax: 82-61-840-0517, Sloveno0@naver.com

Received 24 May 2011       Accepted 24 March 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To identify factors associated with variability in measures obtained by spectral domain optical coherence tomography (SD-OCT).

Methods

One hundred ninety-six subjects (370 eyes) with no ophthalmic evidence of retinopathy and with corrected visual acuities better than 0.6 were included. Macular thickness and retinal nerve fiber layer (RNFL) thickness were measured using SD-OCT and were analyzed according to sex, laterality, age, spherical equivalent and signal strength.

Results

The central subfield thickness was significantly lower in the female subjects (r = -0.260, p = 0.000). As age increased, average inner and outer macular thickness increased significantly (r = 0.153, p = 0.010; r = 0.193, p = 0.001). Spherical equivalent correlated negatively with central subfield thickness (r = -0.352, p = 0.000) but correlated positively with average inner macular thickness, average outer macular thickness, overall average thickness, overall macular volume, and average RNFL thickness (r = 0.181, p = 0.002; r = 0.287, p = 0.000; r = 0.346, p = 0.000; r = 0.341, p = 0.000; and r = 0.261, p = 0.000, respectively). Signal strength correlated negatively with average inner macular thickness (r = -0.136, p = 0.023).

Conclusions

SD-OCT shows that retinal thickness is related to age, sex, spherical equivalent and signal strength. Analysis of retinal thickness by SD-OCT should be interpreted in the context of these findings.

Keywords: Age, Sex, Signal strength, Spectral domain optical coherence tomography, Spherical equivalent

Figures and Tables

Figure 1
ETDRS subfields within standard 1-, 3-, and 6-mm-diameter concentric circles at the right used for reporting retinal thickness. ETDRS = Early Treatment of Diabetic Retinopathy Study. F = fovea; SI = superior inner; NI = nasal inner; II = inferior inner; TI = temporal inner; SO = superior outer; NO = nasal outer; IO = inferior outer; TO = temporal outer.
jkos-53-639-g001
Table 1
Baseline characteristics of subjects
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Table 2
Macular subfield thicknesses and retinal nerve fiber layer thicknesses stratified by sex
jkos-53-639-i002

*Values are presented as n or mean ± SD; †Independent samples t-test between males and females; ‡Partial correlation analysis adjusted by laterality, age, spherical equivalent, and signal strength; §Partial correlation coefficients.

Table 3
Macular subfield thicknesses and retinal nerve fiber layer thicknesses stratified by laterality
jkos-53-639-i003

*Values are presented as n or mean ± SD; †Independent samples t-test between males and females; ‡Partial correlation analysis adjusted by sex, age, spherical equivalent, and signal strength; §Partial correlation coefficients.

Table 4
Correlations between zOCT measurements and age, spherical equivalent, and signal strength
jkos-53-639-i004

p-values and correlation coefficients of partial correlation analysis.

RNFL = retinal nerve fiber layer.

*Adjusted for sex, laterality, spherical equivalent, and signal strength; †Adjusted for sex, laterality, signal strength and age; ‡Adjusted for sex, laterality, age and spherical equivalent.

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