Abstract
Purpose
To evaluate the therapeutic efficacy of intravitreal bevacizumab (IVB) in the treatment of branch retinal vein occlusion (BRVO) in eyes with normal tension glaucoma (NTG).
Methods
We included 16 NTG eyes and 48 age- and sex-matched eyes without NTG that had received IVB for BRVO with more than 6 months of follow-up. The main outcome measures were log MAR best-corrected visual acuity (BCVA) and central macular thickness (CMT) at baseline and 1, 3, and 6 months after IVB. We compared the results according to the comorbidity associated with NTG.
Results
The obstruction site of BRVO was significantly closer to the optic disc in eyes with NTG than in eyes without NTG. Baseline log MAR BCVA and CMT were similar between the two groups. After IVB, postoperative BCVA was significantly improved and CMT was significantly reduced, irrespective of the comorbidity associated with NTG. However, vision improvement was more limited in eyes with NTG, while CMT was similarly reduced compared with that in eyes without NTG. The mean numbers of injections were similar between the two groups, and there were no injection-related complications.
Figures and Tables
Figure 1
Fundus and red-free photographs of a branch retinal vein occlusion (BRVO) patient (A, B), who had been diagnosed with normal tension glaucoma based on glaucomatous optic disc and visual field defect correspond with inferior diffuse retinal nerve fiber layer defect before the onset of BRVO (C, D). M acular edema improved after invtravitreal bevacizumab (IVB) therapy on optical coherence tomography at baseline and post IVB therapy 1, 3, 6 months, respectively (E, F, G, H).
![jkos-53-632-g001](/upload/SynapseData/ArticleImage/0035jkos/jkos-53-632-g001.jpg)
Figure 2
Changes in log MAR visual acuity after bevacizumab therapy for macular edema secondary to branch retinal vein occlusion. NTG = normal tension glaucoma.
![jkos-53-632-g002](/upload/SynapseData/ArticleImage/0035jkos/jkos-53-632-g002.jpg)
Figure 3
Changes in central macular thickness after bevacizumab therapy for macular edema secondary to branch retinal vein occlusion. NTG = normal tension glaucoma.
![jkos-53-632-g003](/upload/SynapseData/ArticleImage/0035jkos/jkos-53-632-g003.jpg)
Table 1
Baseline clinical features of patients receiving intravitreal injection of bevacizumab for macular edema secondary to branch retinal vein occlusion (BRVO) with or without normal tension glaucoma (NTG)
![jkos-53-632-i001](/upload/SynapseData/ArticleImage/0035jkos/jkos-53-632-i001.jpg)
Values are presented as number or mean ± SD.
R = right; L = left; S = superior; I = inferior; M = macular; CMT = central macular thickness; BCVA = best-corrected visual acuity.
*Indicates the frequencies of obstruction sites of BRVO that are divided into two patterns. ONH indicates that the obstruction site is located within 500 µm from the optic disc. AV indicates that the obstruction site is located at the arteriovenous crossing site.
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