Journal List > J Korean Ophthalmol Soc > v.53(4) > 1009340

TOOLS
Koo, Kim, and Kim: A Case of Subconjunctival Foreign Body Migration after Collagen-Containing Filler Injection
Case Report
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(4): 588-591.

Published online: 17 April 2012

DOI: https://doi.org/10.3341/jkos.2012.53.4.588

A Case of Subconjunctival Foreign Body Migration after Collagen-Containing Filler Injection

Nam Kyun Koo, MD1, Yu Cheol Kim, MD2, Kwang Soo Kim, MD2

1Department of Ophthalmology, Dongkang Hospital, Ulsan, Korea.

2Department of Ophthalmology, Dongsan Medical Center, Keimyung University College of Medicine, Daegu, Korea.

Address reprint requests to Kwang Soo Kim, MD. Department of Ophthalmology, Dongsan Medical Center, Keimyung University, #56 Dalseong-ro, Jung-gu, Daegu 700-712, Korea. Tel: 82-53-250-7706, Fax: 82-53-250-7705, kimks@dsmc.or.kr

Received 6 January 2011       Accepted 16 March 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To report a case of subconjunctival foreign body migration in both eyes after collagen-containing filler injection.

Case summary

A 51-year-old female, who had been treated with collagen-containing filler in her eyelid, nose, and forehead for cosmetic complaints four months earlier, presented to our clinic with decreased visual acuity and foreign body sensation in both eyes. Slit lamp examination revealed moderate nucleosclerosis and subcapsular opacity in her crystalline lens, in addition to scattered subconjunctival foreign body infiltration in both eyes. Cataract extraction with posterior chamber lens implantation was performed, and the subconjunctival foreign body was also partially removed. Biopsy of the remaining foreign body was performed, and examination revealed foreign material and multivacuolated cells in the conjunctiva.

Conclusions

Clinicians and patients should be aware of the risk of migration of collagen-containing filler inject at or near the eyelid, to the eyeball, including the conjunctiva.

Keywords: Collagen, Conjunctiva, Migration

Figures and Tables

Figure 1
Subconjunctival infiltration of collagen implant after collagen-containing filler injection on both eyelid.
jkos-53-588-g001
Figure 2
Removed 2 × 1 mm sized subconjunctival foreign body.
jkos-53-588-g002
Figure 3
Histologic findings of the conjunctiva. (A, B) Microscopic findings revealed multiple multivacuolated cell (arrow) due to foreign body reaction (H&E stain, ×40, ×400).
jkos-53-588-g003

References

1. Hoffmann C, Schuller-Petrovic S, Soyer HP, Kerl H. Adverse reactions after cosmetic lip augmentation with permanent biologically inert implant materials. J Am Acad Dermatol. 1999. 40:100–102.
2. Alcalay J, Alkalay R, Gat A, Yorav S. Late-onset granulomatous reaction to Artecoll. Dermatol Surg. 2003. 29:859–862.
3. Engelman DE, Bloom B, Goldberg DJ. Dermal fillers: complications and informed consent. J Cosmet Laser Ther. 2005. 7:29–32.
4. Ellis DA, Makdessian AS, Brown DJ. Survey of future injectables. Facial Plast Surg Clin North Am. 2001. 9:405–411.
5. Lemperle G, Morhenn V, Charrier U. Human histology and persistence of various injectable filler substance for soft tissue augmentation. Aesthetic Plast Surg. 2003. 27:354–366.
6. Lowe NJ, Maxwell CA, Patnaik R. Adverse reactions to dermal fillers: review. Dermatol Surg. 2005. 31:1616–1625.
7. Danesh-Meyer HV, Savino PJ, Sergott RC. Case reports and small case series: ocular and cerebral ischemia following facial injection of autologous fat. Arch Ophthalmol. 2001. 119:777–778.
8. Lemperle G, Romano JJ, Busso M. Soft tissue augmentation with artecoll: 10-year history, indications, techniques, and complications. Dermatol Surg. 2003. 29:573–587.
9. Jo YJ, Lee DG, Lee SB. Late onset migrated inflammatory gran uloma after collagen-containing filler injection. J Korean Ophthalmol Soc. 2008. 49:1330–1334.
10. Jung BY, Kim YD. Orbital dermoid cysts presenting as subconjunctival fat droplets. Ophthal Plast Reconstr Surg. 2008. 24:327–329.
11. Heltzer JM, Ellis DS, Stewart WB, Spencer WH. Diffuse nodular eyelid lipogranuloma following sutureless transconjunctival blepharoplasty dressed with topical ointment. Ophthal Plast Reconstr Surg. 1999. 15:438–441.
12. Fenton S, Canninga-van Dijk MR, Mourits MP. Lipogranuloma of the nasolacrimal system, an iatrogenic and preventable entity. Eye (Lond). 2003. 17:528–530.
13. Doh SH, Lee SK, Yang SW. A case of primary lipogranuloma in eyelid. J Korean Ophthalmol Soc. 2008. 49:2001–2005.
TOOLS
Similar articles