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Lee, Choi, Lee, and Yoon: Prevalence and Clinical Aspects of Sjögren Syndrome in Dry Eye Patients
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(4): 499-504.

Published online: 17 April 2012

DOI: https://doi.org/10.3341/jkos.2012.53.4.499

Prevalence and Clinical Aspects of Sjögren Syndrome in Dry Eye Patients

Jun Sung Lee, MD1, Won Choi, MD1, Shin Seok Lee, MD2, Kyung Chul Yoon, MD, PhD1

1Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea.

2Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Address reprint requests to Kyung Chul Yoon, MD, PhD. Department of Ophthalmology, Chonnam National University Hospital, #42 Jebong-ro, Dong-gu, Gwangju 501-757, Korea. Tel: 82-62-220-6741, Fax: 82-62-227-1642, kcyoon@chonnam.ac.kr

Received 6 September 2010       Accepted 25 February 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To investigate the prevalence and clinical aspects of Sjögren syndrome in patients who were diagnosed with dry eye syndrome in Korea.

Methods

The medical records of patients who were diagnosed with dry eye syndrome in a dry eye clinic during a 2-year period (March 2008 to March 2010) and were followed up for more than 3 months were reviewed retrospectively.

Results

A total of 206 patients were included in the present study. Fifty-eight patients (28%) had Sjögren syndrome and 39 patients (19%) showed primary Sjögren syndrome. Sjögren syndrome patients showed poorer results than non-Sjögren syndrome patients in ocular surface disease index score (OSDI), tear break up time, Schirmer test score, and ocular surface staining score using the Oxford scheme (p < 0.05). Among the patients with primary Sjögren syndrome, 27 patients were SSA (anti-Ro antibodies) or SSB (anti-La antibodies) positive and 12 patients were sero-negative. There were no statistically significant differences in objective or subjective parameters between the sero-positive and sero-negative groups.

Conclusions

Sjögren syndrome was observed in 28% of all dry eye patients, in two-thirds of severe dry eye patients. Sjögren syndrome patients showed more severe clinical aspects than dry eye patients with non-Sjögren syndrome. Diagnosing Sjögren syndrome through systemic evaluation is necessary in the patients with severe dry eye.

Keywords: Autoantibodies, Dry eye, Prevalence, Sjögren syndrome

Figures and Tables

Table 1
Clinical characteristics of patients with dry eye syndrome
jkos-53-499-i001

Values are presented as number (%).

Table 2
Time of diagnosis of Sjögren's syndrome
jkos-53-499-i002

Values are presented as number (%).

Table 3
Clinical feature comparison between Sjögren's syndrome and non-Sjögren's syndrome patients
jkos-53-499-i003

Values are presented as number or mean ± SD.

OSDI = ocular surface disease index.

Table 4
Ocular surface disease index (OSDI) score comparison between Sjögren's syndrome and non-Sjögren's syndrome in the patients with Oxford scheme grade II or more, and III or more
jkos-53-499-i004

Values are presented as mean ± SD.

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