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Joo, Lee, and Joo: Risk Factors of Graft Failure in Post-Keratoplasty Ocular Hypertension
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(3): 385-389.

Published online: 15 March 2012

DOI: https://doi.org/10.3341/jkos.2012.53.3.385

Risk Factors of Graft Failure in Post-Keratoplasty Ocular Hypertension

Jongsoo Joo, MD, You Kyung Lee, MD, Choun-Ki Joo, MD, PhD

Department of Ophthalmology and Visual Science, The Catholic University of Korea School of Medicine, Seoul, Korea.

Address reprint requests to Choun-Ki Joo, MD, PhD. Department of Ophthalmology, Seoul St. Mary's Hospital, The Catholic University of Korea, #222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea. Tel: 82-2-2258-7621, Fax: 82-2-599-7405, ckjoo@catholic.ac.kr

Received 12 November 2010       Accepted 13 February 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To assess the risk factors proceeding to graft failure in post-keratoplasty ocular hypertension patients.

Methods

In 35 eyes diagnosed with post-keratoplasty ocular hypertension (graft failure: 13 eyes; graft survival: 22 eyes), relationships between graft status at the observation time and pre-keratoplasty diagnosis, lens status, history of graft failure, donor size, difference between donor and recipient graft size, donor corneal endothelial cell count, post-keratoplasty intraocular pressure (after 1 week and maintenance intraocular pressure after surgery), and number of antiglaucomatic agents were investigated. The relative risks of each factor to induce graft failure were also evaluated.

Results

Previous graft failure history, pre-existing pseudophakic bullous keratopathy and aphakia/pseudophakia showed statistically significant high probabilities of proceeding to graft failure (p < 0.05). In particular, the intraocular pressure 1 week after the graft was statistically higher (p < 0.05) in the graft failure group (24.31 ± 8.82 mm Hg) than in the graft survival group (16.81 ± 6.69 mm Hg).

Conclusions

Strict management of intraocular pressure in the early phase of penetrating keratoplasty could contribute to reducing graft failure in post-keratoplasty ocular hypertension patients.

Keywords: Graft failure, Penetrating keratoplasty, Post-keratoplasty ocular hypertension

Figures and Tables

Table 1
The incidence rate of post-keratoplasty ocular hypertension according to preoperative diagnosis
jkos-53-385-i001
Table 2
Baseline characteristics, postoperative intraocular pressure, risk factors for graft failure in the graft survival and graft failure group
jkos-53-385-i002

*Mann-Whitney U test; †Chi-square test; ‡Mean period between penetrating keratoplasty and the diagnosis of graft failure; §Intraocular pressure 1 week after keratoplasty.

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