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Yang and Lee: Long-Term Endothelial Cell Changes after Angle-Supported Anterior Chamber Lens Implantation in Phakic Eyes
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(2): 208-214.

Published online: 15 February 2012

DOI: https://doi.org/10.3341/jkos.2012.53.2.208

Long-Term Endothelial Cell Changes after Angle-Supported Anterior Chamber Lens Implantation in Phakic Eyes

Jenny Yang, MD, Jin Ki Lee, MD, PhD

Department of Ophthalmology, Daegu Fatima Hospital, Daegu, Korea.

Address reprint requests to Jin Ki Lee, MD, PhD. Department of Ophthalmology, Daegu Fatima Hospital, #99 Ayang-ro, Dong-gu, Daegu 701-600, Korea. Tel: 82-53-940-7140, Fax: 82-53-940-7417, cornea21@hanmail.net

Received 25 July 2011       Accepted 8 December 2011

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To evaluate long-term endothelial cell changes in phakic eyes that underwent implantation of an angle-supported anterior chamber lens to correct myopia.

Methods

A retrospective analysis was performed in 110 eyes of 55 patients who underwent implantation of angle-supported anterior chamber lenses with a follow-up period longer than 5 years. Comparisons were made between preoperative and postoperative endothelial cell density, coefficient of variation, and percentage of hexagonal cells.

Results

Mean preoperative corneal endothelial cell density was 2951 ± 336 cells/mm2 and the percentage of cell loss was 3.8% at year 1, 12.6% at year 3, 13.4% at year 5, 22.5% at year 7, and 22.2% at year 9. Explantation was required in 13 eyes (11.8%) due to the decrease of endothelial cell count to 936 ± 458 cells/mm2 over 9 years of follow-up.

Conclusions

Continuous endothelial cell loss was observed after implantation of angle-supported anterior chamber lens in the long-term follow-up. A constant decline in the endothelial cell density necessitates periodic ophthalmologic evaluation including specular microscopy.

Keywords: Angle-supported anterior chamber lens, Endothelial cell loss

Figures and Tables

Figure 1
Phakic intraocular lens (PIOL) explantation. Kaplan-Meier survival table. After 112 months of follow-up, 88.18% of cases will retain the PIOL in place.
jkos-53-208-g001
Table 1
Patient characteristics
jkos-53-208-i001

UCVA = uncorrected visual acuity; BSCVA = best spectacle-corrected visual acuity.

Table 2
Mean endothelial cell density (ECD) and standard deviation (SD) over 9 years
jkos-53-208-i002

*Paired t-test between postoperative and preoperative measurements.

Table 3
Mean coefficient of variation (CV) over 9 years
jkos-53-208-i003

*Paired t-test between postoperative and preoperative measurements.

Table 4
Mean percentage of hexagonal cells (6A) over 9 years
jkos-53-208-i004

*Paired t-test between postoperative and preoperative measurements.

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