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Hwang, Shin, Lee, Song, and Kwon: Treatment of Recurrent Conjunctival Papilloma with Topical Mitomycin C
Case Report
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(12): 1889-1892.

Published online: 17 December 2012

DOI: https://doi.org/10.3341/jkos.2012.53.12.1889

Treatment of Recurrent Conjunctival Papilloma with Topical Mitomycin C

Jae Hyeong Hwang, MD1, Kyung Hoon Shin, MD1, Sung Ki Lee, MD, PhD2, Ji Sun Song, MD, PhD3, Ji Won Kwon, MD, PhD1

1Department of Ophthalmology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea.

2Shin Han Eye Clinic, Goyang, Korea.

3Department of Pathology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea.

Address reprint requests to Ji Won Kwon, MD, PhD. Department of Ophthalmology, Kwandong University College of Medicine, Myongji Hospital, #55 Hwasu-ro 14beon-gil, Deogyang-gu, Goyang 412-826, Korea. Tel: 82-31-810-6250, Fax: 82-31-969-0500, eyeminerva@naver.com

Received 30 June 2012       Accepted 13 November 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To provide a case report of 1 patient (1 eye) who experienced recurrences of conjunctival papilloma and was treated with complete resection, electrocauterization, cryotherapy, intraoperative application of mitomycin C and postoperative topical mitomycin C.

Case summary

We evaluated the clinical course of a 42-year-old male with recurrent conjunctival papillomas on the left upper and lower tarsal conjunctiva who was treated 10 times with a simple resection over the past 8 years. The patient was treated with complete resection, electrocauterization, intraoperative application of mitomycin C and cryotherapy. Topical mitomycin C was applied for 1 month. There was no recurrence or complications for 12 months postoperatively.

Conclusions

Complete resection, electrocauterization, intraoperative application of mitomycin C, cryotherapy and topical mitomycin C in patients with recurrent conjunctival papilloma was shown to be an effective treatment without recurrence and complications.

Keywords: Cryotherapy, Mitomycin C, Recurrnet conjunctival papilloma

Figures and Tables

Figure 1
Anterior segment photograph before (A, B) and after (C, D) surgery. Flat papillomas on the surface of the upper (A) and lower (B) tarsal conjunctiva before surgery. One year after surgery, there is no recurrence of the mass or complications (C, D).
jkos-53-1889-g001
Figure 2
Light microscopic view reveals multiple fibrovascular fronds (arrows) covered by non-keratinizing stratified squamous epithelium (arrowheads), characteristic pathologic features of papilloma. (H&E stain, ×100, scale line represents 50 micrometers).
jkos-53-1889-g002

References

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6. Frucht-Pery J, Rozenman Y. Mitomycin C therapy for corneal intraepithelial neoplasia. Am J Ophthalmol. 1994. 117:164–168.
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