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Kang, Hwang, Kim, and Lee: The Effect of Hemodialysis on Intraocular Pressure, Retinal Nerve Fiber Layer Thickness and Corneal Thickness
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(11): 1657-1662.

Published online: 19 November 2012

DOI: https://doi.org/10.3341/jkos.2012.53.11.1657

The Effect of Hemodialysis on Intraocular Pressure, Retinal Nerve Fiber Layer Thickness and Corneal Thickness

Yong Seok Kang, MD1, Young Hoon Hwang, MD2, Jae Suk Kim, MD1, Joo Hwa Lee, MD1

1Department of Ophthalmology, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

2Myung-Gok Eye Research Institute, Department of Ophthalmology, Kim's Eye Hospital, Konyang University, Daejeon, Korea.

Address reprint requests to Joo Hwa Lee, MD. Department of Ophthalmology, Inje University Sanggye Paik Hospital, #1342 Dongil-ro, Nowon-gu, Seoul 139-707, Korea. Tel: 82-2-950-1096, Fax: 82-2-935-6904, joohlee@paik.ac.kr

Received 10 February 2012       Accepted 16 October 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To compare the intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness and central corneal thickness (CCT) in healthy individuals and patients with chronic renal failure (CRF) undergoing hemodialysis, and to evaluate the changes in each parameter before and after hemodialysis in patients with CRF.

Methods

Thirty-six eyes of 36 patients with CRF undergoing hemodialysis were included in the hemodialysis group and 54 eyes of 54 healthy subjects were recruited as the control group. All subjects underwent a complete eye examination, including best-corrected visual acuity (BCVA), slit lamp examination, dilated funduscopic examination, gonioscopy, automated perimetry, IOP measurement, corneal pachymetry, and evaluation of RNFL thickness. In the hemodialysis group, IOP, RNFL thickness, and CCT were measured again within 1 hour of hemodialysis.

Results

Age, sex, BCVA, cup-to-disc ratio, IOP, and CCT were not statistically different between the 2 groups. The RNFL of the hemodialysis group was statistically significantly thinner than the control group (p < 0.001). The IOP decreased from 16.52 ± 2.95 mm Hg to 14.88 ± 2.03 mm Hg after hemodialysis (1.63 ± 3.27 mm Hg; p = 0.005). The changes in RNFL thickness and CCT were not statistically significant (p = 0.148, p = 0.352).

Conclusions

In CRF patients with hemodialysis, RNFLs were thinner in the control group and hemodialysis induced significant IOP reduction. The results from the present study should be considered for the proper evaluation of ocular disorders in CRF patients with hemodialysis.

Keywords: Central corneal thickness, Chronic renal failure, Hemodialysis, Intraocular pressure, Retinal nerve fiber layer thickness

Figures and Tables

Table 1
Characteristics of the overall subjects
jkos-53-1657-i001

Values are presented as number or mean ± SD.

*Fisher's exact test; †Unpaired t-test.

Table 2
Comparison of parameters before and after hemodialysis in patients with hemodialysis group
jkos-53-1657-i002

Values are presented as mean ± SD.

*Paired t-test.

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