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Noh, Ahn, Han, and Seo: Changes in Corneal Keratometry Readings after Corneal Collagen Cross-Linking Using Alcohol in Keratoconus Patients
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(11): 1591-1596.

Published online: 19 November 2012

DOI: https://doi.org/10.3341/jkos.2012.53.11.1591

Changes in Corneal Keratometry Readings after Corneal Collagen Cross-Linking Using Alcohol in Keratoconus Patients

Si Jin Noh, MD1, Ji Min Ahn, MD2, Kyung Eun Han, MD1, Kyoung Yul Seo, MD, PhD1

1The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.

2Siloam Eye Hospital, Seoul, Korea.

Address reprint requests to Kyoung Yul Seo, MD, PhD. Department of Ophthalmology, Yonsei University Severance Hospital, #50 Yeonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Tel: 82-2-2228-6984, Fax: 82-2-312-0541, seoky@yuhs.ac

Received 2 March 2012       Accepted 8 October 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To evaluate the changes in corneal keratometry (K) readings after corneal collagen cross- linking (CXL) using 20% alcohol in primary keratoconus and keratectasia after refractive surgery.

Methods

Twelve eyes of 10 patients with primary keratoconus and 3 eyes of 3 patients with keratectasia after refractive surgery were included in the present study. Best-corrected visual acuity (BCVA) and mean K, corneal astigmatism by corneal topography, and mean K, corneal astigmatism, and spherical equivalent (SE) by auto refractometer were evaluated at baseline, and 6 months postoperatively. Eight eyes of 7 patients were also evaluated 1 year postoperatively.

Results

Mean BCVA improved from log MAR 0.66 ± 0.50 to log MAR 0.55 ± 0.58 (p = 0.100) at 6 month after CXL. In corneal topography, mean K significantly decreased from 50.04 ± 5.88 D to 49.18 ± 6.15 D (p = 0.019), and corneal astigmatism slightly decreased from 5.33 ± 4.47 D to 5.29 ± 4.88 D (p = 0.755) at 6 months after CXL. According to the auto refractometer, mean K significantly decreased from 48.53 ± 5.94 D to 47.95 ± 5.79 D (p = 0.038), corneal astigmatism significantly decreased from 3.95 ± 2.54 D to 3.52 ± 2.40 D (p = 0.010), and SE significantly decreased from -6.25 ± 3.45 D to -5.40 ± 2.91 D (p = 0.037) at 6 months after CXL. Significant mean K and corneal astigmatism decreases in topography were also observed at 1 year after CXL. Complications related to CXL were not observed.

Conclusions

CXL using 20% alcohol appears to be a safe and promising treatment modality with less corneal stromal damage in progressive primary keratoconus and keratectasia after refractive surgery.

Keywords: Corneal collagen cross-linking, Keratectasia, Keratoconus, Keratometry

Figures and Tables

Table 1
Increase in maximal K, mean K, corneal astigmatism in corneal topography and spherical equivalent in auto refractometer at preoperative evaluation compared with 1 year before corneal collagen cross-linking
jkos-53-1591-i001

Values are presented as mean ± SD.

CXL = corneal collagen cross-linking; Max K = maximal keratometry; Mean K = mean keratometry; SE = spherical equivalent.

*Statistically significant (p < 0.05), Wilcoxon signed rank test.

Table 2
Mean value of parameters 6 months and 1 year after corneal collagen cross-linking
jkos-53-1591-i002

Values are presented as mean ± SD.

CXL = corneal collagen cross-linking; BCVA = best corrected visual acuity; Mean K = mean keratometry; SE = spherical equivalent.

*Statistically significant (p < 0.05), Wilcoxon signed rank test.

Table 3
Estimated mean keratometry without corneal collagen cross-linking and postoperative mean keratometry at 6 months and 1 year in corneal topography
jkos-53-1591-i003

Values are presented as mean ± SD.

CXL = corneal collagen cross-linking; Mean K = mean keratometry.

*Statistically significant (p < 0.05), Wilcoxon signed rank test.

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