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Jeong and Ahn: The Effect of Mitomycin C Instillation after Silicone Intubation in Adult Partial Nasolacrimal Duct Obstruction
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(9): 1231-1235.

Published online: 17 September 2012

DOI: https://doi.org/10.3341/jkos.2012.53.9.1231

The Effect of Mitomycin C Instillation after Silicone Intubation in Adult Partial Nasolacrimal Duct Obstruction

Jin Gu Jeong, MD1, Min Ahn, MD1, 2

1Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea.

2Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.

Address reprint requests to Min Ahn, MD. Department of Ophthalmology, Chonbuk National University Hospital, #20 Geonji-ro, Deokjin-gu, Jeonju 561-712, Korea. Tel: 82-63-250-1960, Fax: 82-63-250-1960, ahnmin@jbnu.ac.kr

Received 26 September 2011       Accepted 14 July 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To compare the result of mitomycin C (MMC) instillation after silicone intubation in partial nasolacrimal duct obstruction in adults according to duration of instillation.

Methods

An instillation of 0.04% MMC eyedrops was performed on 61 eyes of 38 patients diagnosed with partial nasolacrimal duct obstruction. The clinical result of patient groups, classified according to duration of MMC eyedrops instillation, was analyzed prospectively. The patients groups was as follows: no MMC eyedrop instillation (group A), 1 week of MMC instillation (group B), 2 weeks of MMC instillation (group C), and 3 weeks of MMC instillation (group D).

Results

Among all patients, 50 eyes (81.9%) showed improved symptoms. Fifteen eyes (71.4%) in group A, 8 eyes (72.7%) in group B, 13 eyes (86.7%) in group C and 14 eyes (100.0%) in group D had a successful outcome. The success rate was observed in groups D, C, B, and A, in descending order, which was statistically significant (p = 0.025).

Conclusions

Silicone intubation is an effective treatment option for partial nasolacrimal duct obstruction in adults and MMC eyedrop instillation may improve silicone intubation results.

Keywords: Mitomycin-C, Nasolacrimal duct obstruction, Silicone intubation

Figures and Tables

Figure 1
Clinical outcome of silicone intubation in partial nasolacrimal duct obstruction. Higher success rate in patients who used MMC instillation after silicone intubation (p < 0.001, Fisher's exact test). MMC = mitomycin C.
jkos-53-1231-g001
Figure 2
Clinical outcome of silicone intubation according to duration of MMC instillation. The success rate increases as the duration of MMC instillation increases (p = 0.025, linear by linear association). MMC = mitomycin C.
jkos-53-1231-g002
Table 1
General characteristics of patients
jkos-53-1231-i001
Table 2
Clinical outcome after removal of silicone tube
jkos-53-1231-i002

*No MMC use; †MMC 1-week instillation; ‡MMC 2-week instillation; §MMC 3-week instillation.

MMC = mitomycin C.

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