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Kim and Kyung: Fluorescein Angiographic Findings of Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(8): 1143-1149.

Published online: 17 August 2012

DOI: https://doi.org/10.3341/jkos.2012.53.8.1143

Fluorescein Angiographic Findings of Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis

Si Bum Kim, MD, Sung Eun Kyung, MD, PhD

Department of Ophthalmology, Dankook University Medical College, Cheonan, Korea.

Address reprint requests to Sung Eun Kyung, MD, PhD. Department of Ophthalmology, Dankook University Hospital, #201 Manghyang-ro, Dongnam-gu, Cheonan 330-715, Korea. Tel: 82-41-550-6490, Fax: 82-41-561-0137, kseeye@hanmail.net

Received 15 November 2011       Accepted 19 June 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To compare the fluorescein angiographic findings of nonarteritic anterior ischemic optic neuropathy (NA-AION) and optic neuritis.

Methods

The present study included 41 patients (41 eyes), who were diagnosed with NA-AION or optic neuritis and underwent fluorescein angiography in our clinic. The clinical profiles of patients, characteristics of optic disc head and hemorrhage, and visual field findings were analyzed retrospectively. The onset and filling time, perfusion time of retinal artery, optic disc, and peripapillary choroid were evaluated quantitatively.

Results

Patients with NA-AION showed statistically significant delay in both the onset time, filling time and perfusion time of the optic disc and peripapillary choroid compared with patients with optic neuritis (p < 0.05). There was no significant difference in the dye leakage of the peripapillary areas between the 2 groups (p = 0.324).

Conclusions

In the present study, the results of fluorescein filling were significantly different between the NA-AION group and the optic neuritis group. The results may help determine the therapeutic plan and to differentiate between the 2 disease entities, especially in cases of overlapping clinical features.

Keywords: Anterior ischemic optic neuropathy, Fluorescein angiography, Optic neuritis

Figures and Tables

Figure 1
Fluorescein angiographic findings of typical case of optic neuritis. Fundus color photograph (A) shows optic disc edema. The fluorescein angiographic finding at 13 seconds (B) shows the beginning of the filling of optic disc head and peripapillary choroid. The finding at 17 seconds (C) shows the complete filling of peripapillary choroid and optic disc head.
jkos-53-1143-g001
Figure 2
Fluorescein angiographic findings of typical case of non-arteritic anterior ischemic optic neuropathy. Fundus color photograph (A) shows optic disc edema with hemorrhage. The fluorescein angiographic finding at 20 seconds (B) shows the delayed filling of peripapillary choroid and optic disc head. The finding at 36 seconds (C) shows complete filling of peripapillary choroid and optic disc.
jkos-53-1143-g002
Table 1
Summary of sex, age, periocular pain, initial & final BCVA, and visual field findings in the two group
jkos-53-1143-i001

Values are presented as mean ± SD or number (%).

ON = optic neuritis; AION = nonarteritic anterior ischemic optic neuropathy; BCVA = best corrected visual acuity.

*Periocular or EOM pain was an exclusion criterion for nonarteritic anterior ischemic optic neuropathy.

Table 2
Comparison of fluorescein angiography data in optic neuritis and nonarteritic anterior ischemic optic neuropathy patients
jkos-53-1143-i002

RAO = retinal artery onset time; CO = peripapillary choroid onset time; CF = peripapillary choroid filling time; CP = peripapillary choroid perfusion time; ODO = optic disc onset time; ODF = optic disc filling time; ODP = optic disc perfusion time.

Table 3
FAG findings, fluorescein leakage at optic disc
jkos-53-1143-i003

Values are presented as number (%).

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