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Kong, Lee, and Kee: Repeatability of Intraocular Pressure Patterns in Glaucomatous Patients
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(8): 1118-1123.

Published online: 17 August 2012

DOI: https://doi.org/10.3341/jkos.2012.53.8.1118

Repeatability of Intraocular Pressure Patterns in Glaucomatous Patients

Mingui Kong, MD, Jeong Min Lee, MD, Changwon Kee, MD, PhD

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Address reprint requests to Changwon Kee, MD, PhD. Department of Ophthalmology, Samsung Medical Center, #81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. Tel: 82-2-3410-3569, Fax: 82-2-3410-0029, ckee@skku.edu

Received 28 November 2011       Accepted 19 June 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To investigate the repeatability of 24-hour intraocular pressure (IOP) patterns in glaucomatous patients.

Methods

The author reviewed bilateral IOP data of 18 glaucoma patients who were admitted for 2 days. IOP data were collected in both eyes every 2 hours using Goldmann applanation tonometry during a 48-hour admission except at 02:00 o'clock (13 patients) and 04:00 o'clock (5 patients). The intraclass correlation coefficient was used to analyze the agreement of IOP patterns between the first and the second 24 hours.

Results

IOP reached its peak between 04:00 o'clock and 06:00 o'clock in both eyes and on both days. On evaluation, the IOP data excluding the results of 02:00 o'clock and 04:00 o'clock, agreement of IOP values of 18 patients was good to excellent at 06:00, 18:00, 20:00, and 24:00 o'clock in both eyes. Agreement of IOP values at 08:00 and 12:00 o'clock was good in the right eye and the left eye, respectively. The agreement of IOP values of 13 patients who underwent IOP assessment at 04:00 o'clock and not at 02:00 o'clock, was good to excellent only at 04:00 and 06:00 o'clock in both eyes. Otherwise, agreement was poor or not significant except at 18:00 and 22:00 o'clock which showed good agreement in the right eye and the left eye, respectively.

Conclusions

Presumable, a circadian IOP pattern exists, because in the present study, IOP reached its peak in the early morning on both days. However, to stipulate IOP patterns were repeatable appears to be difficult since there were numerous time points with poor agreement.

Keywords: Diurnal, Glaucoma, Intraocular pressure, Repeatability, Twenty-four-hour

Figures and Tables

Figure 1
Twenty-four-hour variations in intraocular pressure (IOP) and blood pressure (BP). IOP reaches its peak between 04:00 and 06:00 o'clock in both eyes and on both days. Out of 18 patients, 5 patients underwent IOP assessment at 02:00 o'clock and 13 patients at 04:00 o'clock.
jkos-53-1118-g001
Figure 2
Forty-eight-hour variation of intraocular pressure (IOP) and blood pressure (BP). The peak and trough points of IOP and BP are not matched.
jkos-53-1118-g002
Table 1
General and medication information of patients
jkos-53-1118-i001

SD = standard deviation.

Table 2
Intraocular pressure (IOP) and mean blood pressure (BP) at each time point on Day 1 and Day 2 and their differences between Day 1 and Day 2
jkos-53-1118-i002

IOP values are expressed as mean ± SD, unless otherwise indicated.

Table 3
Intraclass correlation coefficients (ICC) and p-value of intraocular pressure between Day 1 and Day 2 by time point
jkos-53-1118-i003

*ICC: excellent; †ICC: good; ‡Exclude IOP results at 04:00 o'clock.

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