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Sung, Oh, and Yoon: Changes in Higher-Order Aberrations after Penetrating Keratoplasty
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(8): 1088-1098.

Published online: 17 August 2012

DOI: https://doi.org/10.3341/jkos.2012.53.8.1088

Changes in Higher-Order Aberrations after Penetrating Keratoplasty

Mi Sun Sung, MD, Han Jin Oh, MD, Kyung Chul Yoon, MD, PhD

Department of Ophthalmology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

Address reprint requests to Kyung Chul Yoon, MD, PhD. Department of Ophthalmology, Chonnam National University Hospital, #42 Jebong-ro, Dong-gu, Gwangju 501-757, Korea. Tel: 82-62-220-6741, Fax: 82-62-227-1642, kcyoon@chonnam.ac.kr

Received 8 November 2011       Accepted 24 June 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To evaluate the changes in corneal higher-order aberrations (HOAs) after penetrating keratoplasty (PKP) and to investigate the factors affecting the changes in corneal HOAs.

Methods

Forty-eight eyes of 48 patients with three different underlying diseases who underwent PKP were retrospectively reviewed. The changes in corneal higher-order aberrations (total root mean square (RMS), coma, trefoil, and spherical aberration) were evaluated with Pentacam (Oculus Inc., Dutenhofen, Germany) at 1, 3, 6, 12, and 18 months postoperatively. Sex, age, underlying disease, suturing method, trephine size of donor, and suture state were analyzed as factors affecting the HOAs changes.

Results

Total RMS values in the PKP eyes were 1.67 ± 0.49 µm at 1 month, 1.63 ± 0.49 µm at 3 months, 1.64 ± 0.51 µm at 6 months, 1.61 ± 0.50 µm at 12 months, and 1.79 ± 0.40 µm at 18 months after surgery (p < 0.01). The values were higher compared with those in the control eyes. Sex, donor trephine size and suture method did not correlate with the HOAs changes. The HOAs in the keratoconus group were higher than those in the corneal opacity group or bullous keratopathy group. At 18 months, HOAs in the suture removed group were higher than those in the suture-remaining group.

Conclusions

Corneal HOAs after PKP were persistently higher than those in the control eyes. The HOAs were higher in patients with keratoconus and in the suture-removed group.

Keywords: Higher-order aberration, Penetrating keratoplasty

Figures and Tables

Figure 1
Changes in best corrected visual acuity (A), mean keratometric power (B), spherical equivalent (C) after penetrating keratoplasty. D = diopter. *p < 0.05 compared with other periods, repeated measures ANOVA.
jkos-53-1088-g001
Figure 2
The changes of higher-order aberrations in the penetrating keratoplasty and control group. RMS = root mean square; PKP = penetrating keratoplasty. *p < 0.01 compared with the control group, paired t-test; †p < 0.05 compared with other periods, repeated measures ANOVA.
jkos-53-1088-g002
Figure 3
Correlation between age and higher-order aberrations including total RMS, coma, trefoil and spherical aberration at 12 months after penetrating keratoplasty. RMS = root mean square.
jkos-53-1088-g003
Figure 4
Comparison of the higher-order aberrations after penetrating keratoplasty according to the original diseases. RMS = root mean square. *p < 0.05 compared with the keratitis group; †p < 0.05 compared with the bullous keratopathy group, Kruskall-W allis test followed by Mann-Whitney U test with Bonfferoni correction.
jkos-53-1088-g004
Figure 5
Comparison of the higher-order aberrations after penetrating keratoplasty according to the suture state at postoperative 18 months. RMS = root mean square. *p < 0.05 campared with the group that suture remained, Mann-Whitney U test.
jkos-53-1088-g005
Table 1
Demographics of 48 patients underwent penetrating keratoplasty
jkos-53-1088-i001

Combined suture = interrupted suture + continuous suture.

Table 2
Comparison of total RMS, coma, trefoil and spherical aberration in the male and female groups after penetrating keratoplasty
jkos-53-1088-i002

Values are presented as mean ± SD.

RMS = root mean square.

*p > 0.05 between the male and female group, Mann-Whitney U test.

Table 3
Comparison of total RMS, coma, trefoil and spherical aberration after penetrating keratoplasty according to donor trephine size
jkos-53-1088-i003

Values are presented as mean ± SD.

RMS = root mean square.

*p > 0.05 between the donor trephine size ≤7.5 mm and donor trephine size >7.5 mm group, Mann-Whitney U test.

Table 4
Comparison of total RMS, coma, trefoil and spherical aberration for eyes after penetrating keratoplasty in combined suture group and interrupted suture group
jkos-53-1088-i004

Values are presented as mean ± SD.

RMS = root mean square.

*p > 0.05 between the interrupted suture and combined suture group, Mann-Whitney U test.

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