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Lee, Kim, Park, Choung, and Khwarg: A Case of Syringocystadenoma Papilliferum of the Eyelid
Case Report
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(7): 1023-1026.

Published online: 13 July 2012

DOI: https://doi.org/10.3341/jkos.2012.53.7.1023

A Case of Syringocystadenoma Papilliferum of the Eyelid

Dae Seung Lee, MD1, 2, Namju Kim, MD1, 3, Hyo Jin Park, MD4, Ho-Kyung Choung, MD1, 5, Sang In Khwarg, MD1, 2

1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

2Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.

3Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea.

4Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.

5Department of Ophthalmology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.

Address reprint requests to Namju Kim, MD. Department of Ophthalmology, Seoul National University Bundang Hospital, #82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 463-707, Korea. Tel: 82-31-787-7376, Fax: 82-31-787-4057, resourceful@hanmail.net

Received 28 November 2011       Accepted 25 May 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To report a case of syringocystadenoma papilliferum that presented as an eyelid nodule.

Case summary

A 37-year-old woman presented with a mass around the punctum in the right lower eyelid margin, which had developed several years earlier and was increasing in size. The mass was a light pinkish nodule consisting of a few smooth-surface papillary lobules. The pathologic findings of the specimen obtained from a shaving biopsy showed a papillary projection which was covered with epithelium and communication with duct-like structures showing glandular configuration in the deep portion of the lesion. EMA-positive cells were found at the invaginated epithelium, implying a glandular epithelial origin. GCDFP-15-positive cells were found in the deep portion of the lesion, implying apocrine differentiation. The findings were compatible with syringocystadenoma papilliferum.

Conclusions

Syringocystadenoma papilliferum should be considered as a differential diagnosis of a solitary eyelid tumor.

Keywords: Eyelid mass, Syringocystadenoma papilliferum

Figures and Tables

Figure 1
(A, B) Pinkish nodule consisting of a few smooth-surface papillary lobules around the punctum in the right lower eyelid.
jkos-53-1023-g001
Figure 2
(A, B) Papillary projection which is covered with epithelium, is communicating with duct-like structures. (H&E, ×40). (C) EMA-positive cells are found at the superficially-located epithelium (arrowheads). Glandular configuration is also seen in the deep portions of the lesion (asterisk) (×400). (D) GCDFP-15-positive cells (black arrow) are found in the deep portions of the lesion, implying apocrine differentiation (×400).
jkos-53-1023-g002

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