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Kim, Na, Lee, and Sung: Correlation Between Central Corneal Thickness and Glaucomatous Damage
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(7): 1002-1010.

Published online: 13 July 2012

DOI: https://doi.org/10.3341/jkos.2012.53.7.1002

Correlation Between Central Corneal Thickness and Glaucomatous Damage

Yoon Jeon Kim, MD, Jung Hwa Na, MD, Youngrok Lee, MD, Kyung Rim Sung, MD, PhD

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Address reprint requests to Kyung Rim Sung, MD, PhD. Department of Ophthalmology, Asan Medical Center, #88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. Tel: 82-2-3010-3680, Fax: 82-2-470-6440, sungeye@gmail.com

Received 12 August 2011       Accepted 21 May 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To evaluate the correlations between central corneal thickness (CCT) and optic disc and retinal nerve fiber layer (RNFL) parameters determined by spectral domain optical coherence tomography (SD OCT) and visual field (VF) global indices.

Methods

The present study included 151 eyes diagnosed with open-angle glaucoma (OAG) and 135 glaucoma suspect (GS) eyes. The CCT, RNFL thickness, optic disc parameters, and VF global indices were measured. The relationships between CCT and RNFL thickness, optic disc parameters, and VF global indices were assessed by linear regression analysis.

Results

Intraocular pressure (IOP, p < 0.001) and VF mean deviation (p = 0.005) in all participants, age (p = 0.017) and IOP (p = 0.003) in the GS group, and IOP (p = 0.002) and inferior RNFL thickness (p = 0.017) in the OAG group were significantly associated with CCT. Among the optic disc parameters, rim area, average cup/disc ratio, and vertical cup/disc ratio were significantly associated with CCT in all participants in the univariate but not multivariate analysis.

Conclusions

Optic disc parameters obtained by SD OCT were not correlated with CCT in the OAG or GS group, while RNFL thickness and VF mean deviation showed associations.

Keywords: Central corneal thickness, Optic disc parameters, Retinal nerve fiber layer thickness, Spectral domain optical coherence tomography, Visual field indices

Figures and Tables

Figure 1
Correlation between (A) central corneal thickness and intraocular pressure and (B) central corneal thickness and mean deviation in open angle glaucoma and glaucoma suspect subjects. (A) R2 = 0.068, p < 0.001. (B) R2 = 0.037, p = 0.001.
jkos-53-1002-g001
Figure 2
Correlation between (A) central corneal thickness and age and (B) central corneal thickness and intraocular pressure in glaucoma suspect subjects. (A) R2 = 0.047, p = 0.011. (B) R2 = 0.064, p = 0.003.
jkos-53-1002-g002
Figure 3
Correlation between (A) central corneal thickness and intraocular pressure and (B) central corneal thickness and inferior retinal nerve fiber layer thickness in open angle glaucoma. (A) R2 = 0.064, p = 0.002. (B) R2 = 0.019, p = 0.091.
jkos-53-1002-g003
Table 1
Comparison between open angle glaucoma and glaucoma suspect groups (Mann Whitney U test & Chi-square test, mean ± SD)
jkos-53-1002-i001

Values are presented as number or mean ± SD.

BCVA = best corrected visual acuity; MR se = manifest refraction spherical equivalent; IOP = intraocular pressure; CCT = central corneal thickness; RNFLT = retinal nerve fiber layer thickness; ONH = optic nerve head; VF = visual field; MD = mean deviation; PSD = pattern standard deviation.

Table 2
Correlation between central corneal thickness and age, BCVA (log MAR), Refractive error, IOP, and structural and functional parameters of glaucoma (Univariate regression analysis)
jkos-53-1002-i002

BCVA = best corrected visual acuity; MR se = manifest refraction spherical equivalent; IOP = intraocular pressure; RNFLT = retinal nerve fiber layer thickness; ONH = optic nerve head; VF = visual field; MD = mean deviation; PSD = pattern standard deviation.

Table 3
Correlation between central corneal thickness and age, BCVA (log MAR), Refractive error, IOP, and structural and functional parameters of glaucoma (Multivariate regression analysis & Backward elimination method, Estimated coefficient (p-value))
jkos-53-1002-i003

BCVA = best corrected visual acuity; MR se = manifest refraction spherical equivalent; IOP = intraocular pressure; RNFLT = retinal nerve fiber layer thickness; ONH = optic nerve head; VF = visual field; MD = mean deviation; PSD = pattern standard deviation.

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