Journal List > J Korean Ophthalmol Soc > v.52(3) > 1009000

Bae, Kim, and Woo: A Case of Muir-Torre Syndrome

Abstract

Purpose

To present a rare case of Muir-Torre syndrome characterized by the association of sebaceous skin tumors and systemic malignancies.

Case summary

A 65-year-old female visited our clinic with an irregular nodular mass of the right lower eyelid, which developed 1 year earlier. An excisional biopsy and lower lid reconstruction with Tenzel's semicircular rotational flap was performed under local anesthesia. Histopathologic examination showed well-differentiated sebaceous cells, consistent with sebaceous adenoma. The patient had undergone total abdominal hysterectomy and lower anterior resection due to endo-metrial cancer and sigmoid colon cancer 5 years before, and nephroureterectomy due to papillary urothelial carcinoma 3 years before. Based on the history of systemic malignancy and sebaceous skin cancer, a diagnosis of Muir-Torre syndrome was made.

Conclusions

When a sebaceous gland tumor of the eyelids is detected, Muir-Torre syndrome should be included in the differential diagnosis, and systemic work-up for the internal malignancy must be performed.

References

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Figure 1.
Clinical photograph showing an irregular nodular mass in the lower tarsal conjunctiva of the right eye.
jkos-52-355f1.tif
Figure 2.
Sebaceous gland adenoma. Microscopically the tumor exhibited a lobular pattern with basaloid cells at the periphery of the lobules with central areas of sebaceous differentiation (hematoxylin and eosin, original magnification ×100 (A), ×400 (B)).
jkos-52-355f2.tif
Figure 3.
The patient's photograph taken 18 months after surgery shows no recurrence.
jkos-52-355f3.tif
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