Comparison of Measured Intraocular Pressure Change According to the Methods of Corneal Refractive Surgery

Hyung Hun Cho; Myoung Hee Park; Yong-Woo Im; Jung-Il Moon

doi:10.3341/jkos.2011.52.3.308

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Cho, Park, Im, and Moon: Comparison of Measured Intraocular Pressure Change According to the Methods of Corneal Refractive Surgery

Original Article

J Korean Ophthalmol Soc 2011;52(3):308-314.

Published online: 7 September 2011

DOI: https://doi.org/10.3341/jkos.2011.52.3.308

Comparison of Measured Intraocular Pressure Change According to the Methods of Corneal Refractive Surgery

Hyung Hun Cho, MD¹, Myoung Hee Park, MD¹, Yong-Woo Im, MD², Jung-Il Moon, MD¹

¹Department of Ophthalmology, The Catholic University of Korea School of Medicine, Seoul, Korea

²Apgujung St. Mary's Eye Center, Seoul, Korea

Address reprint requests to Jung-Il Moon, MD Department of Ophthalmology, St. Mary's Hospital, The Catholic University of Korea #62 Yeouido-dong, Yeongdeungpo-gu, Seoul 150-713, Korea Tel: 82-2-3779-1243, Fax: 82-2-761-6869, E-mail: jimoon@catholic.ac.kr

Received 28 January 20107 September 2010 Accepted 13 October 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate differences in intraocular pressure change after three different methods of corneal refractive surgery.

Methods

The medical records of 296 eyes of 150 patients who underwent corneal refractive surgery were reviewed. Spherical equivalent, central corneal thickness (CCT), and intraocular pressure before surgery, and one month, three months and six months after surgery were analyzed.

Results

The patients included those having undergone laser-assisted in situ keratomileusis (LASIK; 96 eyes), IntraLASIK (98 eyes), laser assisted subepithelial keratomileusis (LASEK; 102 eyes). Post operative intraocular pressure in ablated corneal depth and in CCT showed a meaningful correlation. Intraocular pressure decreased significantly after refractive surgery; however, there were no differences among the three groups.

Conclusions

Post operative intraocular pressure after corneal refractive surgery is influenced by CCT. There were no differences in intraocular pressure change among the three groups.

Keywords: Central corneal thickness, Intraocular pressure, Refractive surgery

References

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Figure 1.

Plot of change in intraocular pressure to change in corneal ablation amount at post operative 3 months (R² =0.112, p<0.05 regression analysis).

Figure 2.

Pre and Post-op mean intraocular pressure in CCT 3 months after refractive surgery; CCT = central corneal thickness.

Table 1.

Patient's demographics

	Total (eyes)(n = 296)	LASIK (n = 96)	Intra-LASIK (n = 98)	LASEK (n = 102)	p-value
Age (mean ± SD, yr)	29.68 ± 5.89	30.16 ± 5.44	28.88 ± 5.92	30.00 ± 6.24	0.253
Sex (M:F)	64:232	23:73	17:81	24:78	0.475
SE^∗ (mean ± SD, Diopter)	-5.36 ± 2.29	-4.97 ± 1.86	-5.58 ± 2.37	-5.53 ± 2.54	0.117
Pre-op CCT^† (mean ± SD, μ m)	535.33 ± 36.64	538.80 ± 38.96	541.21 ± 63.78	504.82 ± 39.89	0.000
Pre-op IOP^‡ (mean ± SD, mmHg)	17.13 ± 2.84	17.65 ± 2.94	17.60 ± 2.62	16.22 ± 2.77	0.000

^∗ SE = spherical equivalent;

^† CCT = central corneal thickness;

^‡ IOP = intraocular pressure.

Table 2.

Postoperative intraocular pressure in three groups

	LASIK (n = 96)	Intra LASIK (n = 98)	LASEK (n = 102)	p-value
	(mean ± SD)	(mean ± SD)	(mean ± SD)	p-value
Preop IOP^∗ (mmHg)	17.65 ± 2.94	17.60 ± 2.62	16.22 ± 2.77	0.000
POD^†1 month	12.81 ± 2.69	14.29 ± 4.46	10.52 ± 2.15	0.000
POD 3 months	12.64 ± 3.18	12.08 ± 3.16	11.46 ± 3.25	0.104
POD 6 months	11.41 ± 3.13	11.99 ± 3.21	10.61 ± 3.14	0.014

^∗ IOP = intraocular pressure;

^† POD = post operative date.

Table 3.

Postoperative intraocular pressure change in three groups

	LASIK (n = 96)	Intra LASIK (n = 98)	LASEK (n = 102)	p-value
	(mean ± SD)	(mean ± SD)	(mean ± SD)	p-value
Δ CCT^∗ (μ m)	77.00 ± 23.38	88.28 ± 28.60	78.30 ± 27.20	0.038
POD^†1 month (mmHg)	5.13 ± 2.94	3.76 ± 3.80	5.47 ± 2.84	0.016
POD 3 months	5.36 ± 2.85	5.62 ± 3.20	4.86 ± 3.12	0.331
POD 6 months	5.76 ± 3.21	4.76 ± 3.64	5.84 ± 2.91	0.316

^∗ Δ CCT = corneal ablation amount;

^† POD = post operative date.

Table 4.

Comparison of intraocular pressure at post operative 3 months according to pre operative central corneal thickness (mmHg)

		LASIK	Intra LASIK	LASEK	p-value
IOP^∗ (mean ± SD, mmHg)		12.64 ± 3.18	12.08 ± 3.16	11.46 ± 3.25	0.104
		(n = 56)	(n = 67)	(n = 80)
CCT^† ((mean ± SD, μ m)	<500	-	10.14 ± 3.89	10.95 ± 3.60	0.561
		(n = 0)	(n = 7)	(n = 42)
	500-550	11.81 ± 2.86	10.82 ± 2.59	11.26 ± 2.40	0.316
		(n = 32)	(n = 34)	(n = 27)
	>550	13.75 ± 3.31	14.27 ± 3.04	13.82 ± 3.09	0.830
		(n = 24)	(n = 26)	(n = 11)

^∗ IOP = intraocular pressure;

^† CCT = central corneal thickness.

Table 5.

Comparison of intraocular pressure at post operative 3 months, according to corneal ablation amount (mmHg)

		LASIK (mean ± SD)	Intra LASIK (mean ± SD)	LASEK (mean ± SD)	p-value
IOP^∗ (mmHg)		12.64 ± 3.18	12.08 ± 3.16	11.46 ± 3.25	0.104
		(n = 56)	(n = 67)	(n = 80)
Δ CCT^† (μ m)	<50	14.33 ± 2.50	12.86 ± 4.34	14.54 ± 3.23	0.569
		(n = 6)	(n = 7)	(n = 13)
	50-100	12.30 ± 3.23	13.44 ± 2.92	10.95 ± 3.13	0.003
		(n = 40)	(n = 34)	(n = 44)
	>100	13.00 ± 3.23	10.11 ± 1.98	10.65 ± 2.66	0.011
		(n = 10)	(n = 26)	(n = 23)

^∗ IOP = intraocular pressure;

^† CCT = central corneal thickness.

Table 6.

Comparison of intraocular pressure at post operative 3 months according to corneal ablation amount in pre operative central corneal thickess 500-550 μ m

		LASIK (mean ± SD)	Intra LASIK (mean ± SD)	LASEK (mean ± SD)	p-value
IOP^∗ (mmHg)		11.37 ± 2.69	10.80 ± 2.46	11.26 ± 2.40	0.660
		(n = 27)	(n = 30)	(n = 27)
Δ CCT^† (μ m)	50-100	11.09 ± 2.72	13.00 ± 2.19	11.29 ± 2.58	0.104
		(n = 22)	(n = 11)	(n = 17)
	>100	12.60 ± 2.40	9.53 ± 1.54	11.20 ± 2.74	0.011
		(n = 5)	(n = 19)	(n = 10)

^∗ IOP = intraocular pressure;

^† Δ CCT = corneal ablation amount.

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