Relationship Between Visual Acuity and Foveation Window in Infantile Nystagmus by Analyzing Nystagmus Waveforms

Jee Ho Chang; Jong Bok Lee; Su Chan Kim; Seung Han Han

doi:10.3341/jkos.2010.51.6.875

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Chang, Lee, Kim, and Han: Relationship Between Visual Acuity and Foveation Window in Infantile Nystagmus by Analyzing Nystagmus Waveforms

Original Article

J Korean Ophthalmol Soc 2010;51(6):875-880.

Published online: 3 June 2010

DOI: https://doi.org/10.3341/jkos.2010.51.6.875

Relationship Between Visual Acuity and Foveation Window in Infantile Nystagmus by Analyzing Nystagmus Waveforms

Jee Ho Chang, MD, PhD¹, Jong Bok Lee, MD², Su Chan Kim, PhD³, Seung Han Han, MD, PhD²

¹Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea

²The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea

³Biosignal Laboratory, Hankyung National University, Suwon, Korea

Address reprint requests to Jong Bok Lee, MD The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine #134 Shinchon-dong, Seodaemun-gu, Seoul 120-140, Korea Tel: 82-2-2228-3574, Fax: 82-2-312-0541, E-mail: 491209@yuhs.ac

Received 23 November 2009 Accepted 23 March 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report herein on Nystagmus Acuity Estimator Function (NAEF) based on the foveation time, obtained by analyzing waveforms of infantile nystagmus patients and comparing the results with the patients’ actual visual acuity.

Methods

Electro-oculographic data of 27 patients with infantile nystagmus were reviewed. Data of patients only with jerk type nystagmus and reliable visual acuity were analyzed. The foveation time was measured, and NAEF was calculated and compared with the patients’ actual best corrected visual acuity.

Results

A correlation analysis of the patients’ best corrected visual acuity with NAEF was performed, and the retrieved coefficient was 0.4266. The p-value calculated using the Pearson correlation coefficient was 0.0282, implying that high NAEF correlates positively with visual acuity.

Conclusions

Estimated visual acuity, calculated based on the waveforms, positively correlates with the patients’ actual visual acuity with statistical significance. However, since the foveation time can be measured only in the patients with jerk-type nystagmus waveforms, further study should be performed on the measurement of the foveation time with other waveforms. Furthermore, the present study shows that such analysis is possible with electrooculogram settings in most general hospitals.

Keywords: Foveation time, Infantile nystagmus, Nystagmus Acuity Estimator Function

References

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Figure 1.

An eye tracing of a 42-year-old male diagnosed with infantile nystagmus shown with our program. Upper graph (Ch A) shows eye positional tracing and lower graph (Ch B) shows eye velocity tracing. Upward deflection denotes rightward direction. First, using cursors (red cross and yellow cross shown on the graph), we identified the interval of ±4°/sec velocity. Second, we check the chosen velocity interval meets the ±0.5° positional criterion. If the interval meets two criteria, we calculate foveation time (Tf) and standard deviation of position (SDp). For de-tails, see the text.

Figure 2.

Relationship between NAEF and best corrected visual acuity (BCVA) (correlation coefficient=0.4266. Pearson correlation coefficients: p-value=0.0282) Horizontal axis denotes BCVA (best corrected visual acuity of patients); vertical axis denotes NAEF (nystagmus acuity estimator function of patients).

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