Journal List > J Korean Ophthalmol Soc > v.51(6) > 1008840

Kim and Lee: The Short-term Effect of Intravitreal Bevacizumab for Treatment of Central Serous Chorioretinopathy

Abstract

Purpose

To determine whether intravitreal bevacizumab is effective for the treatment of central serous chorioretinopathy.

Methods

We retrospectively examined 42 eyes after intravitreal bevacizumab (1.25 mg) injection for central serous chorioretinopathy. After 1 month, improvement of vision and change in sensory retinal detachment were evaluated with a fundus examination and optical coherence tomography.

Results

The mean duration of symptoms was 3.9±2.31 months. After intravitreal bevacizumab injection, mean best corrected visual acuity improved from 0.53±0.31 to 0.72±0.29 at 1 month. In addition, neurosensory retinal detachment disappeared in 32 patients (76.2%). Five patients among ten who did not show improvement of neurosensory retinal detachment underwent reinjection of bevaczumab, and three of those reinjected showed the resolution of neurosensory retinal detachment at another 1 month. No improvement was seen among the patients who did not undergo reinjection.

Conclusions

Intravitreal bevacizumab injection appears to have a short-term benefit for the treatment of central serous chorioretinopathy.

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Figure 1.
(A) Fluorescein angiograph of a patient with central serous chorioretinopathy showing a focal leakage. (B) Optical coherence tomograph (OCT) before treatment showing subfoveal neurosensory retinal detachment. (C) OCT showing resolution of neurosensory retinal detachment after intravitreal bevacizumab injection.
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Table 1.
Profile of the patients undergoing intravitreal bevacizumab injection for treatment of central serous chorioretinopathy
Male : Female (No.) 37 : 5
Average age (yesrs) 45±6.4 (range, 29∼51)
Symptom duration (months) 3.9±2.31 (range, 3∼7)
Primary event : Recurrent event (No.) 37 : 5
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