Clinical Features of Nevus of Ota in Korean Population

Seong Joon Ahn; Ji Won Kwon; Young Keun Han; Won Ryang Wee; Jin Hak Lee

doi:10.3341/jkos.2010.51.12.1579

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Ahn, Kwon, Han, Wee, and Lee: Clinical Features of Nevus of Ota in Korean Population

Original Article

J Korean Ophthalmol Soc 2010;51(12):1579-1583.

Published online: 7 September 2010

DOI: https://doi.org/10.3341/jkos.2010.51.12.1579

Clinical Features of Nevus of Ota in Korean Population

Seong Joon Ahn, MD¹, Ji Won Kwon, MD¹, Young Keun Han, MD^1,², Won Ryang Wee, MD¹, Jin Hak Lee, MD^1,³

¹Department of Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea

²Department of Ophthalmology, Seoul National University Boramae Hospital, Seoul, Korea

³Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea

Address reprint requests to Ji Won Kwon, MD Department of Ophthalmology, Seoul National University Hospital #28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel: 82-2-2072-2438, Fax: 82-2-741-3187, E-mail: eyeminerva@yahoo.co.kr

Received 16 March 2010 Accepted 11 October 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To investigate the clinical features of the nevus of Ota in the Korean population.

Methods

A retrospective chart review of the medical records from 94 patients (100 eyes), diagnosed to have a nevus of Ota from September 2005 to February 2010, was performed.

Results

The mean age of detection of a nevus of Ota was 8 months, and the mean extent of the nevus was 253 degrees, which covered more than 2 quadrants in most cases. The patients with a faint nevus tended to be younger. Pigmentation did not reach the fornix, but the limbus was mostly pigmented. Combined conjunctival pigmentation was observed in 61.7% of cases. The pigmentation was significantly associated with a greater extent of the nevus. Iris pigmentation was demonstrated in 98.7% of cases.

Conclusions

The clinical features of nevi of Ota were diverse regarding the location, extent, and color of the lesion. Conjunctival pigmentation was associated with the extent of the nevus. Iris pigmentation was revealed in almost all cases; therefore, this feature had the diagnostic value for a nevus of Ota. Young patients with a nevus of Ota may mimic osteo-genesis imperfecta, which necessitates careful consideration upon differential diagnosis.

Keywords: Clinical features, Nevus of Ota

References

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Figure 1.

Manifestations of nevus of Ota. (A) Skin pigmentation with scleral pigmentation. (B) Iris pigmentation compared to contralateral eye without nevus of Ota (inside box). (C) Conjunctival pigmentation (black arrow), scleral (blue arrow) and deeper scleral (green arrow) pigmentation. (D, E) Anterior segment photograph of patients in dark group (D) and that of patient in faint group (E).

Figure 2.

The association between conjunctival pigmentation and the extent of nevus (Error bar indicates 95% confidence interval).^* Statistically significant (p value <0.001) by Student's t test.

Table 1.

Quadrant location and extent of Ota nevus

Location	No. of eyes (%)
Inferotemporal	67 (88.2)
Superotemporal	64 (84.2)
Inferonasal	61 (80.3)
Superonasal	52 (68.4)
Extent	
All (4) quadrants	50 (65.8)
3 quadrants	10 (13.2)
2 quadrants	18 (23.7)
1 quadrant	4 (5.3)

Table 2.

Darkness of pigmentation and its association with patient's age

	No. of eyes (%)	Patient age (yr)
Faint group	19 (23.5)	10.9 ± 8.66^*
Dark group	62 (76.5)	24.6 ± 12.4^*
P value	Not applicable	< 0.001

^* Denotes mean ± standard deviation.

^* P value was obtained by Student's t-test.

Table 3.

Location of extrascleral pigmentation and its incidence

Location	No. of eyes (%)
Conjunctiva	50 (61.7)
Iris	80 (98.7)

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