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Kim and Lee: Effects of Amount of Myopic Correction on Long-term Changes in Higher-order Wavefront Aberrations in ASA-PRK
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2010; 51(9): 1184-1195.

Published online: 30 September 2010

DOI: https://doi.org/10.3341/jkos.2010.51.9.1184

Effects of Amount of Myopic Correction on Long-term Changes in Higher-order Wavefront Aberrations in ASA-PRK

Jin-Seon Kim, MD, Sang-Bumm Lee, MD, PhD

Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea.

Address reprint requests to Sang-Bumm Lee, MD, PhD. Department of Ophthalmology, Yeungnam University Medical Center, #317-1 Nam-gu, Daemyeong-dong, Daegu 705-717, Korea. Tel: 82-53-620-3445, Fax: 82-53-626-5936, sbummlee@med.yu.ac.kr

Received 18 January 2010       Accepted 13 June 2010

Copyright © 2010 The Korean Ophthalmological Society

Abstract

Purpose

To evaluate the effects of the amount of myopic correction on long-term changes in higher-order wavefront aberrations (HOAs) in advanced surface ablation-photorefractive keratectomy (ASA-PRK).

Methods

The 193 eyes of 101 patients who underwent ASA-PRK were divided into two groups according to the amount of myopic correction by the median value (Group 1 ≤ -4.37D, 97 eyes, mean -3.26 ± 0.77D; Group 2 > -4.37D, 96 eyes, mean -5.77 ± 1.00D). Wavefront aberrometry was performed to measure total HOA, coma, trefoil, and spherical aberration preoperatively and at 1, 3, 6, 12, and 24 months after ASA-PRK. Statistical analysis was performed to compare changes in all HOAs between the two groups.

Results

Each magnitude of total HOA, coma, and spherical aberration except trefoil significantly increased at 1, 3, 6, 12, and 24 months postoperatively in each group (p<0.05), and the increases were statistically significantly higher in group 2 compared to those of group 1 (p<0.05). The amount of changes in all HOAs except trefoil revealed that statistically significantly higher increases in group 2 compared to those of group 1 were determined only in the short-term period (up to 1 month, p<0.05), but not in the medium-term (1 to 6 months) or long-term periods (6 to 24 months).

Conclusions

Postoperative total HOA, coma, and spherical aberration significantly increased in both groups, and these increases in surgery-induced HOAs were significantly higher in group 2 (> -4.37D). Increases in ASA-PRK-induced HOAs primarily originated from short-term changes in the postoperative one-month period and did not return to the preoperative level during the postoperative two-year period.

Keywords: ASA-PRK, Higher-order wavefront aberration, Long-term change, Myopic correction, PRK

Figures and Tables

Figure 1
The relationship between ASA-PRK-induced HOAs including total HOA, coma, trefoil, and spherical aberration and the amount of myopic correction for overall 193 eyes.
*p<0.05, simple linear regression analysis; †Postop = postoperative; ‡m = months; §n = number of eyes; ∥HOA = higher-order wavefront aberration; #SA = spherical aberration; ΦR2 = regression coefficients; θSEop = spherical equivalent at operation.
jkos-51-1184-g001
Figure 2
Time course of change in higher-order wavefront aberrations during postoperative 24 months after PRK in group I (myopic correction ≤ -4.37D). Bars indicate standard error of the mean.
*p<0.05, paired t-test; †Preop = preoperative; ‡m = months; §HOA = higher-order wavefront aberration; ∥SA = spherical aberration.
jkos-51-1184-g002
Figure 3
Time course of change in higher-order wavefront aberrations during postoperative 24 months after PRK in group II (myopic correction > -4.37D). Bars indicate standard error of the mean.
*p<0.05, paired t-test; †Preop = preoperative; ‡m = months; §HOA = higher-order wavefront aberration; ∥SA = spherical aberration.
jkos-51-1184-g003
Table 1
Patient demographics and baseline characteristics of 193 eyes according to amount of myopic correction before ASA-PRK
jkos-51-1184-i001

*independent t-test; †χ2 test; ‡OD = right eye; §OS = left eye; ∥D = diopters; #SD = standard deviation.

Table 2
Change of higher-order wavefront aberrations according to the amount of myopic correction during postoperative 24 months
jkos-51-1184-i002

Values are RMS for total HOA and Zernike coefficients for coma, trefoil, and spherical aberration (µm, mean ± SD). Group I: myopic correction ≤ -4.37D (n = 97), Group II: myopic correction > -4.37 D (n = 96). Numbers of eyes in group I and II (97/96 preoperatively) at each postoperative follow-up visits were 91/89 at 1 month, 84/84 at 3 months, 74/84 at 6 months, 46/61 at 1 year, and 29/32 at 2 years.

*p<0.05 (independent t-test) compared between group I and II; †Preop = preoperative; ‡Postop = postoperative; §m = months; ∥RMS = root mean square; #HOA = higher-order wavefront aberration.

Table 3
The amount of changes in all HOAs in terms of 3 time periods
jkos-51-1184-i003

Values are RMS for total HOA and Zernike coefficients for coma, trefoil, and spherical aberration (µm, mean ± SD).

*p<0.05 (independent t-test) compared between group I and II; †preop = preoperative; ‡postop = postoperative; §m = months; ∥RMS = root mean square; #HOA = higher-order wavefront aberration.

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