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Abstract
Purpose
To evaluate the therapeutic effects of topical heparin (Hylo-Parin®, Ursapharm Saarbr cken, Germany) and spray type phospholipids (Tears Again®, Optima Pharmazeutische GmbH. Freising, Germany) in severe dry eye syndrome resistant to conventional therapy.
Methods
Twenty eyes of ten patients with refractory severe dry eye were treated with Hylo-Parin® (two times a day) and Tears Again® (three times a day) for three months. Before and one and three months after treatment, a symptom questionnaire was administered to the patients. The ocular surface disease index (OSDI), tear film breakup time, Schirmer test, conjunctival fluorescein staining examinations and filamentary keratitis were evaluated.
Results
After using Tears Again® and Hylo-Parin®, the OSDI score improved from 64.13 ± 15.12 to 43.80 ± 15.87 (p＜0.01). Tear film breakup time significantly increased from 1.0 ± 0.65 to 2.3 ± 0.73 seconds (p＜0.01) and conjunctival staining score (Oxford scale) significantly decreased from 3.85 ± 0.75 to 3.25 ± 0.97 (p＜0.01). Filamentary keratitis in the slit-lamp examination showed significant improvement (p＜0.01).
References
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Figure 1.
Changes in ocular surface disease index score (A), Tear breakup time (B), Schirmer test (C) and Oxford grading (D) before and 1, 3 months after treatment with Hylo-Parin® and Tears Again®.
Figure 2.
Amounts of BUT change in BUT 20 eyes. After treatment for 3 months, BUT increased by 2 seconds in 9 eyes and 1 second in 6 eyes. There was no interval change in BUT in 5 eyes.
Figure 3.
Patient with keratoconjunctivitis sicca and filamentary keratitis were treated with Tears Again® and Hylo-Parin®. The right eye shows severe corneal erosions (A). After 3-months treatment, corneal erosions are healed (B). Left eye shows severe corneal erosions and filaments (C). After 3-months treatment, corneal erosions and filaments are improved (D).
Figure 4.
In patient with a history of recurrent herpetic epithelial keratitis, corneal erosion, plaque, and filaments are observed (A). Three months after treatment with Tears Again® and Hylo-Parin®, multiple filaments and corneal erosions disappeared completely (B).
Table 1.
Constituents of Tears Again® and Hylo-Parin® (1 ml contains)
Table 2.
Demographic data
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