Sang Won Moon; Yumi Song; Hee Yoon Cho; Byung Ro Lee; Jun Hong Sohn; Young Sook Park

doi:10.3341/jkos.2009.50.10.1595

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Moon, Song, Cho, Lee, Sohn, and Park: The Effect of Intravitreal Bevacizumab Injection in Eales’ Disease

Original Article

J Korean Ophthalmol Soc 2009;50(10):1595-1599.

Published online: 3 August 2009

DOI: https://doi.org/10.3341/jkos.2009.50.10.1595

The Effect of Intravitreal Bevacizumab Injection in Eales’ Disease

Sang Won Moon, MD¹, Yumi Song, MD¹, Hee Yoon Cho, MD¹, Byung Ro Lee, MD¹, Jun Hong Sohn, MD², Young Sook Park, MD²

¹Department of Ophthalmology, College of Medicine, Hanyang University Hospital, Seoul, Korea

²HanGil Eye Hospital, Incheon, Korea

Address reprint requests to Young Sook Park, MD HanGil Eye Hospital #543-36 Bupyeong-dong, Bupyeong-gu, Incheon 403-010, Korea Tel: 82-32-503-3322, Fax: 82-32-504-3322, E-mail: parkys73@lycos.co.kr

Received 23 March 2009 Accepted 14 July 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report on 2 cases of Eales’ disease that were successfully regressed with laser photocoagulation and intravitreal bevacizumab (Avastin; Genetech, Inc, San Francisco, California, USA) injection.

Case summary

Two male patients (30 years and, 40 years of age,) with a history of recurrent vitreous hemorrhage were diagnosed with Eales’ disease. The 2 patients had peripheral retina neovascularization and active phlebitis in fundus fluorescein angiography. No other findings were observed in their eyes in the general examination. Scatter laser photocoagulation and intravitreal bevacizumab injection were performed. After 1 month follow-up, neovascularization completely regressed. There was no complication or recurrent vitreous hemorrhage at the 1 year follow up.

Conclusions

Intravitreal bevacizumab injection, as combination treatment of laser photocoagulation, may be helpful in the regression of neovascularization due to Eales’ disease.

Keywords: Eales’ disease, Intravitreal bevacizumab injection, Laser photocoagulation

References

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Figure 1.

Fundus photographs and fluorescein angiographs of Case 1. (A) Fundus photograph showing active periphlebitis and slcerosed vein with subhylaoid hemorrhage. Fibrovascular prolife-ration causing tractional retinal membrane seen also at juxtafoveolar area. There was late fluorescein leakage due to neovascularization at the optic disc and peripheral retina (white arrows). (B) Montage fundus photography shows successfully regressed neovascularization of the optic disc and peripheral retina six weeks after panretinal photocoagulation and intravitreal bevacizumab injection. There was no progression of fibrovascular membrane.

Figure 2.

Fundus photographs and fluorescein angiographs of Case 2. (A) There were vascular obliterance and sheath in the nasal retina. And fibrovascluar membrane was observed in the peripheral inferior nasal retina (white arrow). Fundus fluorecein angiogram shows large non-perfusion area and late leakage at the neovascularization site. (B) One month after scatter laser photocoagulation and intravitreal bevacizumab injection, neovascularization regressed and vitreous hemorrhage did not recur.

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