Retinal Vasculopathy as First Manifestation of Chronic Myelogenous Leukemia

In Tae Kim; Jin Woo Kwon

doi:10.3341/jkos.2009.50.9.1418

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Kim and Kwon: Retinal Vasculopathy as First Manifestation of Chronic Myelogenous Leukemia

Original Article

J Korean Ophthalmol Soc 2009;50(9):1418-1422.

Published online: 7 September 2009

DOI: https://doi.org/10.3341/jkos.2009.50.9.1418

Retinal Vasculopathy as First Manifestation of Chronic Myelogenous Leukemia

In Tae Kim, MD, Jin Woo Kwon, MD

Department of Ophthalmology and Visual Science, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea

Address reprint requests to In Tae Kim, MD Department of Ophthalmology and Visual Science, College of Medicine, St. Mary's Hospital, The Catholic University of Korea #62 Yeouido-dong, Yeongdeungpo-gu, Seoul 150-713, Korea Tel: 82-2-3779-1243, Fax: 82-2-761-6869, E-mail: kimintae@catholic.ac.kr

Received 13 October 2008 Accepted 9 June 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To present a case of bilateral retinal vasculopathy as the first manifestation of chronic myelogenous leukemia.

Case summary

A 59-year-old man with no medical history such as diabetes, hypertension and no ocular history complained of decreased visual acuity for 1 month. Fundus examinations showed diffuse multiple dot and blot hemorrhages over the panretina of both eyes and vessels showed tortuous vascular changes. The fluorescein angiogram was evaluated, and showed diffuse microaneurysms at the peripheral retina and posterior pole. Hematologic and biochemical examinations as well as a carotid sonogram were performed based on the possibility of systemic disease. The patient showed hematologic abnormality and therefore was transferred to internal medicine for diagnosis of chronic myelogenous leukemia.

Conclusions

The authors examined a chronic leukemia patient, who showed bilateral retinal vasculopathy as the first manifestation of chronic myelogenous leukemia. This case shows the importance of considering the possibility of systemic disease.

Keywords: Chronic myelogenous leukemia, Retinal vasculopathy in leukemia

References

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Figure 1.

Fundus color photographs of the patient showed diffuse multiple dot and blot hemorrhages throughout the retina of both eyes.

Figure 2.

Central macular OCT examinations showed retinal thickening with macular edema in both eyes.

Figure 3.

Fluorescein angiogram showed diffuse microaneurysms and ischemia at the peripheral retina and posterior pole and leakage around the disc.

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