Abstract
Purpose
To evaluate the relationship between intraocular pressure (IOP) and age, blood pressure and obesity index inocular hypertensive patients.
Methods
A total of 2684 ocular hypertensive patients underwent automated multi-phasic testing, including fundus photography, blood pressure and assessment of obesity. The subjects were divided into six age groups by decades ranging from 20∼29 years to over 70 years of age. The relationships between factors were examined using multiple regression analysis.
Results
The mean participant age was 48.0±11.0 years, and 1,777 (66.3%) participants were male and 907 (33.7%) were female. The mean intraocular pressure (IOP) was 22.04±2.2 mmHg and was significantly higher in males than in females (p=0.023). The IOP was associated with mean blood pressure, gender and obesity index. After adjustment for mean blood pressure and obesity index, the relationship between IOP and age showed a significantly negative tendency (p<0.001). The relationship between IOP and obesity index adjusted for age and mean blood pressure had a significantly positive tendency (p<0.001), regardless of gender. The relationship between IOP and mean blood pressure adjusted for age and obesity index showed a significantly positive tendency (p=0.00014).
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Table 1.
Table 2.
Variables | Female | Male | Total |
---|---|---|---|
Mean age (years) | 47.6±10.9 | 48.2±11.2 | 48.0±11.1 |
Mean IOP† (mm Hg) | 21.83±2.4 | 22.12±2.5* | 22.04±2.2 |
Degree of obesity‡ (%) | 119.52±40.3* | 115.14±13.2 | 116.59±32.4 |
Mean BP§ (mm Hg) | 105.17±16.4 | 106.34±15.2* | 106.10±13.7 |
Table 3.
| | MBP† | Age | Obesity index‡ |
---|---|---|---|---|
| Pearson's | 0.073 | −0.093 | 0.057 |
| coefficient of | | | |
IOP* | correlation | | | |
| p value | 0.00014 | 0.000001 | 0.0008 |
| N | 2,684 | 2,684 | 2,684 |
Table 4.
|
Male |
||||||
---|---|---|---|---|---|---|---|
| IOP | Age | SBP | DBP | MBP | Obesity index | |
Female | IOP* | 1 | −0.094# | 0.070# | 0.054# | 0.062# | 0.042# |
| Age | −0.078# | 1 | 0.206# | 0.183# | 0.198# | 0.003 |
| SBP† | 0.079# | 0.400# | 1 | 0.906# | 0.971# | 0.269# |
| DBP‡ | 0.088# | 0.353# | 0.907# | 1 | 0.981# | 0.265# |
| MBP§ | 0.086# | 0.384# | 0.973# | 0.980# | 1 | 0.273# |
| Obesity index∏ | 0.036# | 0.116# | 0.124# | 0.144# | 0.138# | 1 |