Clinical Analysis of Anisometropic Amblyopia with Monocular Vision 0.1 or Worse

Mi Young Choi; Youn Hui Kim

doi:10.3341/jkos.2008.49.6.973

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Choi and Kim: Clinical Analysis of Anisometropic Amblyopia with Monocular Vision 0.1 or Worse

Original Article

J Korean Ophthalmol Soc 2008;49(6):973-978.

Published online: 8 September 2008

DOI: https://doi.org/10.3341/jkos.2008.49.6.973

Clinical Analysis of Anisometropic Amblyopia with Monocular Vision 0.1 or Worse

Mi Young Choi, M.D., Youn Hui Kim, M.D.

Department of Ophthalmology, Chungbuk National University College of Medicine, Chungbuk National University Medical Research Institute, Cheongju, Korea

Address reprint requests to Mi Young Choi, M.D. Department of Ophthalmology, College of Medicine, Chungbuk National University Hospital #62 Kaeshin-dong, Heungduk-gu, Cheongju 361-711, Korea Tel: 82-43-269-6335, Fax: 82-43-264-5263, E-mail: mychoi@chungbuk.ac.kr

26 February 2008 Accepted 14 June 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To analyze the results of treatment in pure anisometrpic amblyopia with unilateral visual acuity of 0.1 or worse.

Methods

The major eligibility criteria included pure anisometropic amblyopia with age <10 years, best-corrected visual acuity 0.1 or worse in the worse eye and 0.5 or better in the good eye after the wearing of optimal spectacle correction for a minimum of 4 weeks, and the minimum follow-up was 6 months. Twenty-one patients were selected and we analyzed the age at the amblyopia treatment, the type and degree of anisometropia, and the final visual acuity after treatment for visual improvement. Successful treatment was defined as a final visual acuity of 0.3 or more.

Results

The mean age at treatment was 5.2 years. The types of anisometropia were hypermetropic in 14 patients, astigmatic in 4, and myopic in 3. The mean duration of treatment of amblyopia was 16 months, and 13 of 21 children with pure anisometropic amblyopia achieved 0.3 or better. The age at treatment was younger and the compliance rate was higher in the success group than in the failure group.

Conclusions

The most common type was hyperopic in the pure anisomteropic amblyopia. Compliance and age at treatment were significantly related to best visual acuity attained in pure anisometropic amblyopia with unilateral visual acuity of 0.1 or worse.

Keywords: Amblyopia, Anisometropia, Hyperopia, Patching therapy

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Table 1.

Comparison of clinical manifestations between success group and failure group

	Success (n=13)	Failure (n=8)	P-value
Age at diagnosis (years, Mean±SD)	4.43±1.12	6.48±1.85	0.039^*
Sex (F:M, No)	7:6	5:3	0.642^†
Visual acuity of better eye, LogMAR	0.17±0.12	0.01±0.23	0.114^*
Degree of anisometropia	4.28±1.38	5.09±2.82	0.812^*
Type of anisometropia (No)
Astigmatism	4	0
Hyperopia	7	7	0.238^‡
Myopia	2	1
Compliance (%)	100.0	37.5	0.000^‡

^* Mann-Whitney U test

^† Fisher’s exact test

^‡ Chi-square test.

Table 2.

Comparison between success group and failure group in hyperopic anisometropia

	Success (n=7)	Failure (n=7)	P-value
Age at diagnosis (years, Mean±SD)	4.53±0.82	6.89±1.29	0.032^*
Sex (F:M, No)	3:4	4:3	0.592^†
Visual acuity of better eye, LogMAR	0.11±0.11	-0.03±0.41	0.199^*
Degree of anisometropia	4.28±1.53	4.25±1.63	0.617^*
Compliance (%)	100.0	28.6	0.000^‡

^* Mann-Whitney U test

^† Fisher’s exact test

^‡ Chi-square test.

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