The Focal Aggravation of the Macular Edema on Optical Coherence Tomography After Intravitreal Triamcinolone Injection

Joo Youn Park; Mi Sun Sung; Sung Jin Lee

doi:10.3341/jkos.2008.49.5.753

Journal List > J Korean Ophthalmol Soc > v.49(5) > 1008262

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Park, Sung, and Lee: The Focal Aggravation of the Macular Edema on Optical Coherence Tomography After Intravitreal Triamcinolone Injection

Original Article

J Korean Ophthalmol Soc 2008;49(5):753-762.

Published online: 7 September 2008

DOI: https://doi.org/10.3341/jkos.2008.49.5.753

The Focal Aggravation of the Macular Edema on Optical Coherence Tomography After Intravitreal Triamcinolone Injection

Joo Youn Park, M.D., Mi Sun Sung, M.D., Sung Jin Lee, M.D.

Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea

Address reprint requests to Sung Jin Lee, M.D. Department of Ophthalmology Soonchunhyang University College of Medicine #657 Hannam-dong, Yongsan-gu, Seoul 140-743, Korea Tel: 82-2-709-9354, Fax: 82-2-798-7797, E-mail: wismile@unitel.co.kr

Received 31 January 2007 Accepted 4 December 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate the relationship between focal aggravation of the macular edema on retinal thickness change analysis (RTCA) of optical coherence tomography (OCT) and fluorescein angiographic findings in patients after an intravitreal triamcinolone injection (IVTA).

Methods

From May 2004 to April 2005, RTCA in a fast macular thickness map (FMTM) of OCT was performed before and 4 weeks after IVTA in patients who had macular edemas caused by diabetic retinopathy and retinal vein occlusion. Patients underwent IVTA, and focal aggravation of the edema was detected. After overlapping the OCT findings onto angiographic pictures, the relationship between the focal aggravation on OCT and the leaking point on angiography was investigated.

Result

In the patient group, focal aggravation was found in 5 of 27 eyes (18.5%); in the control group, only 2 of 30 eyes (6.7%) showed focal aggravation. As compared with angiographic pictures, 4 eyes with focal aggravation showed no relation to the leakage on angiography.

Conclusions

Focal aggravation of macular edemas after IVTA on RTCA are not related to the leakage on angiography and could be an error from several artifacts.

Keywords: Focal aggravation, Intravitreal triamcinolone injection, Macular edema, Optical coherence tomography, Retinal thickness change analysis

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Figure 1.

Case 1. Preinjetion (A) and postinjection (B) OCT fast macular thickness map (FMTM) findings. Retinal thickness change analysis change (RTCA, C left) shows peripheral abnormal thickening after IVTA. There is no correlation between focal aggravation on RTCA and fluorescein angiographic image (C right).

Figure 2.

Case 2. Preinjetion (A) and postinjection (B) OCT fast macular thickness map (FMTM) findings. There is a mismatch between average thickness value (B center) and focal aggravation area on retinal thickness change analysis (RTCA, C left). RTCA shows central abnormal thickening after IVTA. There is no correlation between focal aggravation on RTCA and fluorescein angiographic image (C right).

Figure 3.

Case 3. Preinjetion (A) and postinjection (B) OCT fast macular thickness map (FMTM) findings. Thickness value between preinjection and postinjection FMTM is mismatched with RTCA color change and it might be an error of OCT. Retinal thickness change analysis change (RTCA, C left) shows central abnormal thickening after IVTA. There is some correlation between focal aggravation on RTCA and fluorescein angiographic image (C right).

Figure 4.

Case 4. Preinjetion (A) and postinjection (B) OCT fast macular thickness map (FMTM) findings. Retinal thickness change analysis change (RTCA, C left) shows peripheral abnormal thickening after IVTA. There is no correlation between focal aggravation on RTCA and fluorescein angiographic image (C right).

Figure 5.

Case 5. Preinjetion (A) and postinjection (B) OCT fast macular thickness map (FMTM) findings. Retinal thickness change analysis change (RTCA, C left) shows peripheral abnormal thickening. There is no correlation between focal aggravation on RTCA and fluorescein angiographic image (C right).

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