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Ahn, Chang, and Kyung: Multifocal Electroretinography After Reattachment of Macula-Off Retinal Detachment
Original Article

J Korean Ophthalmol Soc 2008;49(3):479-486.

Published online: 7 September 2008

DOI: https://doi.org/10.3341/jkos.2008.49.3.479

Multifocal Electroretinography After Reattachment of Macula-Off Retinal Detachment

Jung Hyun Ahn, M.D., Moo Hwan Chang, M.D., Seong Eun Kyung, M.D.

Department of Ophthalmology, Dankook University College of Medicine, Cheonan, Korea

Address reprint requests to Moo Hwan Chang, M.D. Department of Ophthalmology, Dankook University College of Medicine #San 16-5 Anseo-dong, Cheonan-si, Chungcheongnam-do 330-714, Korea Tel: 82-41-550-6377, FAX: 82-41-561-0137, E-mail: changmh@dankook.ac.kr

Received 28 June 2007       Accepted 31 October 2007

Copyright © 2008 Korean Ophthalmological Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To assess macular function by multifocal electroretinography after reattachment of macula-off retinal detachment and to evaluate relationship between duration of macular detachment (DMD) and functional recovery.

Methods

Nineteen patients (19 eyes) with macula-off rhegmatogenous retinal detachment underwent pneumatic retinopexy or scleral buckling. Retinal reattachment was obtained successfully in all patients. Duration of follow-up of all patients is at least more than 12 months. Eyes were divided into 2 groups, corresponding to the DMD: Group A (within 7 days, n=9 eyes), Group B (>7 days, n=10 eyes). The amplitudes and implicit times of N1-wave and P1-wave of mfERGs in Area 1 (Ring 1), Area 2 (Ring 1+2) were compared between Group A and B and between Group A and control group.

Results

The P1 amplitudes in Area 1 and 2 were significantly different between Group A and B (P<0.05). N1 amplitudes in Area 1 were significantly different between Group A and B (P<0.05), but no significant difference of P1 amplitudes in Area 2 between Group A and B (P>0.05). There were no significant difference of all data between Group A and control in Area 1 and 2 (P>0.05) The implicit times of N1, P1 were not significantly different between Group A and B.

Conclusions

The DMD plays a key role in recovery of visual function after reattachment. The mfERG is a useful tool to evaluate the recovery of macular function after reattachment of macula-off retinal detachments.

Keywords: Macular detachment, Multifocal electroretinography, Rhegmatogenous retinal detachment

References

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Figure 1.
Stimulus array of 61 hexagonal elements; ring 1 (red) and ring 2 (blue) correspond to fovea and parafovea, respectively.
jkos-49-479f1.tif
Figure 2.
The typical waveform of the primary multifocal ERG response is a biphasic wave with initial negative deflection followed by a positive peak. There may be a second negative deflection after the peak. The preferred designation is to label these three peaks respectively N1, P1, and N2.
jkos-49-479f2.tif
Figure 3.
Comparison of P1 amplitudes of Group A, B, and control. The box-and-whiskers plots include the 25 th, 50 th, and 75 th percentiles. The whiskers define the minimum and maximum values. Figure 3A and 3B show data in Area 1 and 2, respectively.
jkos-49-479f3.tif
Figure 4.
Comparison of N1 amplitudes of Group A, B, and control. The box-and-whiskers plots include the 25 th, 50 th, and 75 th percentiles. Except for outliers, the whiskers define the minimum and maximum values. Figure 4A and 4B show data in Area 1 and 2, respectively.
jkos-49-479f4.tif
Table 1.
Comparisons of clinical data of two groups
Features Group A Group B p-value
Number of eyes 9 10  
Age (years, mean±SD) 40.2±14.0 55.6±19.6 0.065*
Sex (Male/Female) 5/4 7/3 0.650†
Duration of macular detachment 4.0±1.8 21.5±7.1 <0.001*
Method of reattachment      
  SB 5 6 1.000†
  PR 4 4  
Refractive error −4.1±1.9 −3.0±1.8 0.182*
BCVA      
  Preoperative      
    < 0.1 5 6  
    0.1∼0.2 4 4  
  Postoperative 0.73±0.1 0.50±0.1 0.004*
Extent of detachment      
  < 1Q 0 0  
  1Q∼3Q 8 8  
  > 3Q 1 2  

PR=pneumatic retinopexy; SB=scleral buckling; BCVA=best corrected visual acuity; Q=quadrant(s)

* Mann-Whitney U test

† Fisher's exact test.

Table 2.
Amplitudes and implicit times of Groups A and B
Parameters Group A Group B p-value
Area 1 Amplitude (nV/deg2)*      
N1 51.50±10.52 35.63±11.33 0.010‡
P1 164.23±12.57 98.84±21.45 <0.001‡
Implicit time (ms)†      
N1 19.02±3.21 20.38±3.00 0.661
P1 40.64±3.44 42.53±3.37 0.400
 
Area 2 Amplitude (nV/deg2)*      
N1 32.07±9.59 23.88±9.04 0.053
P1 95.03±9.10 65.71±17.69 0.001‡
Implicit time (ms)†      
N1 20.11±2.11 22.75±3.19 0.053
P1 41.35±2.77 41.74±3.28 0.905

All values are presented as mean±standard deviation unless otherwise indicated.

* nV/deg2=nanovolt/square degrees

† ms=millisecond

‡ Statistically significant (P<0.05), Mann-Whitney U test.

Table 3.
Amplitudes and implicit times of Group A and control group
Parameters Group A Control p-value‡
Area 1 Amplitude (nV/deg2)*      
N1 51.50±10.52 59.82±17.04 0.498
P1 164.23±12.57 173.06±17.83 0.172
Implicit time (ms)†      
N1 19.02±3.21 20.24±2.50 0.332
P1 40.64±3.44 40.17±2.55 0.699
Area 2 Amplitude (nV/deg2)*      
N1 32.07±9.59 41.50±9.17 0.054
P1 95.03±9.10 103.57±10.72 0.068
Implicit time (ms)†      
N1 20.11±2.11 20.27±1.56 0.699
P1 41.35±2.77 39.37±1.89 0.095

All values are presented as mean±standard deviation unless otherwise indicated.

* nV/deg2=nanovolt/square degrees

† ms=millisecond

‡ Mann-Whitney U test.

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