Abstract
Purpose
To report a case of solitary Kaposi’s sarcoma (KS) of eyelid in an HIV-negative patient, which has not yet been reported in domestics.
Case summary
A 76-year-old woman was seen at our clinic with a purplish nodular mass on her left lower lid that had grown up for 4 months prior. There were no abnormal findings in the body except eyelid. In the routine laboratory examinations, the result of HIV test was negative. The lesion was completely excised and the eyelid was reconstructed by semicircular rotational flap procedure. The histopathologic examination showed spindle cells of mild atypism, intermixed with slit-like vascular spaces and red blood cell extravastaion. These findings coincided with KS and polymerase chain reaction was positive for human herpes virus-8. During 10 months follow up, there was no evidence of tumor recurrence and systemic abnormalities.
References
1. Kaposi M. Idiopatisches multiples pigmentsarkom der haut. Arch Dermatol Syphilis. 1872; 4:265.
2. Dammacco R, Lapenna L, Giancipoli G. . Solitary eyelid Kaposi sarcoma in an HIV-negative patient. Cornea. 2006; 25:490–2.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
3. Reiser BJ, Mok A, Kukes G. . Non-AIDS-related Kaposi sarcoma involving the tarsal conjunctiva and eyelid margin. Arch Ophthalmol. 2007; 125:838–40.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
4. Yanoff M, Fine BS. Ophthalmology. 4th ed. St. Louis: Mosby;1998. 7:p. 12–7.
5. Hengge UR, Ruzicka T, Tyring SK. . Update on Kaposi's sarcoma and other HHV-8 associated diseases. Lancet Infect Dis. 2002; 2:344–52.
6. Beral V, Peterman TA, Berkelman RL. . Kaposi’s sarcoma among persons with AIDS: a sexually transmitted infection? Lancet. 1990; 335:123–8.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
7. Shuler JD, Holland GN, Miles SA. . Kaposi sarcoma of the conjunctiva and eyelids associated with the AIDS. Arch Ophthalmol. 1989; 10:858–62.
8. Chang Y, Cesarman E, Pessin MS. . Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994; 266:1865–9.
9. Kedes DH, Operskalski E, Busch M. . The seroepi- demiology of human herpesvirus 8 (Kaposi’s sarcoma- associated herpesvirus). Nat Med. 1996; 2:918–24.
Figure 2.
(A) Immediate postoperative photograph after performing semicircular flap surgery to reconstruct tumor excision site of the lower lid (postoperative 1 day). (B) Photograph shows well reconstructed lower lid (posto-perative 2 months).
![jkos-49-1671f2.tif](/upload/SynapseXML/0035jkos/thumb/jkos-49-1671f2.gif)
Figure 3.
(A) A sarcomatoid lesion is formed by spindle cells and clusters of many small capillaries (hematoxylin-eosin, ×100). (B) The vascular neoplasm is consisted of immature spindle cells with mild atypism and plump endothelial cells that line slit-like vascular channels. Extravasated red blood cells in slit-like channels and hyperchromatic nuclei in spindle cells were also observed (hematoxylin-eosin, ×400).
![jkos-49-1671f3.tif](/upload/SynapseXML/0035jkos/thumb/jkos-49-1671f3.gif)