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Abstract
Purpose
To report two cases of conjunctival mucosa-associated lymphoid tissue (MALT) lymphomas treated with cryotherapy.
Case summary
Two patients with MALT lymphoma of the conjunctiva were treated by carbon dioxide cryotherapy under topical anesthesia using 0.5% proparacaine hydrochloride (Alcaine®, Alcon). Cryotherapy was repeated in recurrent lesions up to three times. One patient was free of the tumor for 18 months of follow-up after the third cryotherapy was performed. The second patient had complete disease arrest for 9 months after the third cryotherapy. Neither patient experienced complications during the follow-up period.
References
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Figure 2.
Case 1. Photographs of the right (A) and left (B) eyes show salmon-patched lesions at the inferior forniceal conjunctiva.
Figure 3.
Case 1. (A) Microscopic examination of conjunctival mass shows massive proliferation of atypical lymphocytes in the conjunctival stroma with invasion of overlying conjunctival squamous epithelium (H&E stain, ×400). (B) Immunohistologic staining for CD20 shows conspicuous positivity of the atypical B lymphocytic cells in the conjunctival stroma (×400).
Figure 5.
Case 1. Photographs of the right (A) and left (B) eyes showing the regression of conjunctival MALT lymphomas at the last follow-up.
Figure 6.
Case 2. Photographs of salmon-patched conjunctival lesions of the left superior (A) and inferior fornices (B).
Figure 7.
Case 2. (A) Microscopic examination of conjunctival mass shows the massive proliferation of anaplastic lymphocytic cells in the conjunctival stroma. (H&E stain, ×200). (B) Immunohistologic staining for CD20 shows the infiltration of tumor cells originated from B lymphocytes in the overlying squamous epithelium (×400).
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