Analysis of RNFL Thickness and Optic Nerve Head Measured with OCT in Children

Ji Hye Song; Eurie Kim; Ji Myong Yoo

doi:10.3341/jkos.2007.48.10.1346

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Song, Kim, and Yoo: Analysis of RNFL Thickness and Optic Nerve Head Measured with OCT in Children

Original Article

J Korean Ophthalmol Soc 2007;48(10):1346-1353.

Published online: 30 August 2007

DOI: https://doi.org/10.3341/jkos.2007.48.10.1346

Analysis of RNFL Thickness and Optic Nerve Head Measured with OCT in Children

Ji Hye Song, M.D., Eurie Kim, M.D., Ji Myong Yoo, M.D.

Department of Ophthalmology, Gyeongsang National University, College of Medicine, Chinju, Korea

Address reprint requests to, Ji Myong Yoo, M.D., Department of Ophthalmology, College of Medicine, Gyeongsang National University, #92 Chilam-dong, Chinju, Gyeong-nam 660-280, Korea, Tel: 82-55-750-8170, Fax: 82-55-758-4158, E-mail: youngongju@yahoo.co.kr

Received 30 March 2007 Accepted 4 July 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To analyze peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters with regard to age in children by using optical coherence tomography (OCT).

Methods

We analyzed RNFL thickness and ONH parameters by using Stratus OCT Model 3000 (Zeiss-Humphrey) in two-hundred eyes of 100 children ranging in age from 5 to 14 years, with 5 males and 5 females for each age.

Results

The RNFL thicknesses for 100 children (200 eyes) in total were as follows: Mean 104.67±9.07 pm, superior 131.84±18.71 pm, temporal 78.49±12.91 pm, nasal 73.85±14.26 pm, and Inferior 133.87±18.58 pm. The parameters of ONH for 100 children (200 eyes) in total were as follows: optic disc area 2.80±0.21 mm², rim area 1.85±0.28 mm², cup to disc area ratio 0.34±0.08, horizontal cup to disc diameter ratio 0.47± 0.11, and vertical cup to disc diameter ratio 0.49±0.11. In analyzed RNFL thickness and ONH according to age, there was a significant negative correlation among mean RNFL, inferior RNFL, and age (r=-0.258, p=0.000, r=-0.464, p=0.000). There was a significant positive correlation between nasal RNFL and age (r=0.135, p=0.028). There was a significant positive correlation between disc area and age (r=0.528, p=0.000). There was a significant negative correlation among the cup to disc area ratio, the horizontal cup to disc diameter ratio, the vertical cup to disc diameter ratio, and age (r=-0.170, p=0.008, r=-0.266, p=0.000, r=-0.155, p=0.014).

Conclusions

OCT can be used to measure RNFL thickness and ONH parameters in children. Age had an effect on RNFL thickness and ONH parameters in children.

Keywords: Age, Children, OCT, Optic nerve head parameter, RNFL thickness

References

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Figure 1.

Retinal nerve fiber layer (RNFL) thickness (pm) in children by age (200 eyes). (A) Mean RNFL thickness, (B) Superior RNFL thickness, (C) Nasal RNFL thickness, (D) Inferior RNFL thickness, (E),Temporal RNFL thickness.

p-value <0.05 as compared with the predictive value.

Correlation coefficient.

Figure 2.

Optic nerve head parameter in children by age (200 eyes). (A) Disc Area, (B) C/D* area ratio, (C) Horizontal C/D ratio, (D) Vertical C/D ratio (D).

p-value <0.05 as compared with the predictive value.

Correlation coefficient.

Cup to Disc.

Table 1.

Study characteristics

Age (year)	5	6	7	8	9	10	11	12	13	14
Gender	5:5	5:5	5:5	5:5	5:5	5:5	5:5	5:5	5:5	5:5
(Male:Female) (No ^*)
Total eyes (No ^*)	20	20	20	20	20	20	20	20	20	20
Mean IOP^† ±SD^‡	14.35	15.90	15.55	16.90	14.65	14.70	13.80	15.05	15.40	15.10
(mmHg)	±2.72	±2.25	±2.56	±1.68	±2.11	±2.03	±1.64	±1.85	±1.82	±1.52
Mean P^§±SD	+0.31	+0.35	+0.55	-0.25	-1.25	-0.25	-0.48	-1.25	-0.45	-0.30
(Diopter)	±1.53	±1.37	±1.22	±1.24	±1.36	±1.31	±1.48	±1.31	±1.25	±1.19

^* : Number.

^† : Intraocular pressure.

^‡ : Standard deviation.

^§ : Refractive power.

Table 2.

Analysis of retinal nerve fiber layer (RNFL) thickness in 100 children (200 eyes).

RNFL (μm)	Mean±SD^∗
Mean	104.67±9.07
Superior	131.84±18.71
Temporal	78.49± 12.91
Nasal	73.85± 14.26
Inferior	133.87± 18.58

^∗ : Standard deviation.

Table 3.

Analysis of optic nerve head parameter in 100 children (200 eyes)

	Mean±SD^*
Disc Area (mm²)	2.80±0.21
Rim Area (mm²)	1.85±0.28
C/D^† area ratio	0.34±0.08
Horizontal C/D ratio	0.47±0.11
Vertical C/D ratio	0.49±0.11

^∗ : Standard deviation.

^† : Cup to Disc.

Table 4.

Analysis of retinal nerve fiber layer (RNFL) thickness according to age

Age (year)	Mean	Superior	Mean±SD^* (μm) Temporal	Nasal	Inferior
5	112.08±6.98	140.30± 16.45	79.10±12.49	76.10±15.88	152.55±11.58
6	102.88±9.05	125.80±31.64	72.30± 10.09	66.75±16.64	140.35±15.76
7	106.13±7.89	135.50±15.26	79.30±15.34	73.60±11.41	136.10±14.90
8	108.01±10.33	139.00±20.92	76.45± 12.33	71.55±19.89	143.25±18.69
9	103.30±7.94	129.70±17.01	79.40± 12.85	68.85±8.13	135.25±15.28
10	104.85±15.74	122.20±23.56	86.40±24.22	76.00±17.59	134.80±28.31
11	104.41±7.50	136.50±15.39	80.00±8.42	75.00±20.47	124.15± 19.52
12	101.68±3.84	130.75±8.14	75.45±6.96	75.85±8.67	124.65±10.08
13	100.56±7.59	128.50±14.07	79.60±7.78	76.20±7.58	120.00±13.50
14	102.81±3.28	130.10±7.23	76.90±6.43	78.65±4.18	125.60±4.69
F^† (p-value)	3.041 (0.002)^‡	2.045 (0.057)	1.678 (0.097)	1.382 (0.199)	7.405(0.000)^‡

^* : Standard deviation.

^† : Total statistics of DUNCAN analysis.

^‡ : p-value <0.05 as compared with the predictive value.

Table 5.

Analysis of optic nerve head parameter according to age

Age (year)	C/D^† area ratio	Mean±SD^∗ Horizontal C/D ratio	Vertical C/D ratio
5	0.354±0.086	0.504±0.081	0.475±0.107
6	0.397±0.104	0.484±0.106	0.488±0.104
7	0.319±0.083	0.550±0.101	0.537±0.106
8	0.357±0.081	0.479±0.072	0.520±0.088
9	0.319±0.073	0.493±0.090	0.513±0.078
10	0.330±0.061	0.453±0.103	0.475±0.129
11	0.382±0.097	0.500±0.091	0.499±0.100
12	0.293±0.086	0.447±0.081	0.472±0.112
13	0.328±0.047	0.456±0.097	0.502±0.097
14	0.320±0.055	0.424±0.087	0.417±0.107
F^‡	3.282	3.062	2.070
(p-value)	(0.001)^§	(0.002)^§	(0.034)^§

^∗ : Standard deviation.

^† : Cup to Disc.

^‡ : Total statistics of DUNCAN analysis.

^§ : p-value <0.05 as compared with the predictive value.

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