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Park, Park, Oh, Yoon, Kim, Lee, Kim, Cho, Woo, Jahng, and Kim: Trend in the Eradication Rates of Helicobacter pylori Infection Over the Last 10 Years in West Gyeonggi-do, Korea: A Single Center Experience
Original Article
Alimentary Tract

The Korean Journal of Gastroenterology 2017; 70(5): 232-238.

Published online: 24 November 2017

DOI: https://doi.org/10.4166/kjg.2017.70.5.232

Trend in the Eradication Rates of Helicobacter pylori Infection Over the Last 10 Years in West Gyeonggi-do, Korea: A Single Center Experience

Jong Seol Park, Ji-Eun Park1, Byoung Soo Oh, Byung Wook Yoon, Hyun Ki Kim, Jae Won Lee, Nam Ho Kim, Won Seok Cho, Young Sik Woo2, Jaehoon Jahng, Yong Sung Kim

Department of Internal Medicine and Wonkwang Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, Gunpo, Korea.

1Graduate School of Public Health, Seoul National University, Seoul, Korea.

2Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Correspondence to: Yong Sung Kim. Department of Internal Medicine and Wonkwang Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, 321 Sanbon-ro, Gunpo 15865, Korea. Tel: +82-31-390-2975, Fax: +82-31-398-2223, wms89@hanmail.net

Received 17 July 2017       Revised 3 August 2017       Accepted 11 August 2017

Copyright © 2017. Korean Society of Gastroenterology

Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims

The eradication rate of Helicobacter pylori (H. pylori) has been decreasing recently in Korea due to antibiotics resistance. The aim of this study was to investigate the trend of eradication rate and clinical factors affecting the eradication rate of H. pylori in the last 10 years in west Gyeonggi-do, Korea.

Methods

The trends of eradication rate of H. pylori, gender, age, concomitant mediations, and clinical factors were retrospectively evaluated in patients with H. pylori infection between 2006 and 2015 (n=2,485).

Results

The overall H. pylori eradication rate for the standard triple therapy was 82.5%. The annual eradication rates from 2006 to 2015 were 90%, 77.9%, 75.8%, 83.2%, 85.6%, 90.1%, 81.3%, 81.1%, 78.7%, and 78.8%, respectively, showing a significant decrement during the last five years (p<0.001). Higher eradication rate was observed in males than in females (p<0.001). Esomeprazole showed a higher eradication rate compared with pantoprazole between 2006 and 2010 (p<0.022). Age and the use of probiotics and mucosal protective agents played no significant role in the H. pylori eradication rate. The overall eradication rate for bismuth-based quadruple therapy was 94.4%.

Conclusions

The eradication rate of H. pylori over the last 10 years for first-line therapy ranged from 75.8 to 90.1%; the eradication rate for triple therapy has declined. However, the eradication rate for quadruple therapy has remained unchanged over the last 10 years.

Keywords: Helicobacter pylori, Disease eradication, Korea

Figures and Tables

Fig. 1

Annual Helicobacter pylori eradication rates from 2006 to 2015 according to regimen and treatment duration.

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Fig. 2

Annual proportion of treatment duration with first-line therapy.

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Table 1

Clinical Factors for Eradication Rate of Helicobacter pylori during the Period 2006-2015

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Values are presented as n (%) unless otherwise indicated.

SD, standard deviation; PPI, proton pump inhibitor; PAN, pantoprazole; LAN, lansoprazole; ESO, esomeprazole; RAB, rabeprazole; OMP, omeprazole; MPAs, mucosal protective agents.

Table 2

Univariate and Multivariate Logistic Regression Analyses of Predictors of Helicobacter pylori Eradication

kjg-70-232-i002

OR, odds ratio; CI, confidence interval; LAN, lansoprazole; PAN, pantoprazole; ESO, esomeprazole; RAB, rabeprazole; MPAs, mucosal protective agents; NA, not available.

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