Rare Case of Primary Gastric Burkitt Lymphoma in a Child

Soon Chul Kim; Jung Won Hwang; Min Kyung Lee; Pyoung Han Hwang

doi:10.4166/kjg.2016.68.2.87

Journal List > Korean J Gastroenterol > v.68(2) > 1007607

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Kim, Hwang, Lee, and Hwang: Rare Case of Primary Gastric Burkitt Lymphoma in a Child

Case Report

Korean J Gastroenterol 2016;68(2):87-92.

Published online: 4 October 2016

DOI: https://doi.org/10.4166/kjg.2016.68.2.87

Rare Case of Primary Gastric Burkitt Lymphoma in a Child

Soon Chul Kim^1,², Jung Won Hwang^1,², Min Kyung Lee^1,², Pyoung Han Hwang^1,²

¹Department of Pediatrics, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea

²Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea

Correspondence to: Pyoung Han Hwang, Department of Pediatrics, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea. Tel: +82-63-250-1460, Fax: +82-63-250-1464, E-mail: hwaph@jbnu.ac.kr

Received 22 February 2016 Revised 31 May 2016 Accepted 1 June 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Primary gastric tumors are very rare in children. Burkitt lymphoma is a common type of non-Hodgkin's lymphoma, and gastric Burkitt lymphoma usually occurs in the aged. When involving the gastrointestinal tract, primary gastric Burkitt lymphoma is very rare in younger childhood. Many gastric lymphomas including mucosa-associated lymphoid tissue lymphoma are associated with Helicobacter pylori infection or acute bleeding symptom. We report a seven-year-old boy who presented with only some vomiting and postprandial pain. His upper gastrointestinal endoscopy and biopsy revealed a large primary Burkitt lymphoma with no acute bleeding and no evidence of H. pylori infection. After chemotherapy, he remains in remission.

Keywords: Burkitt lymphoma, Gastric cancer, Non-Hodgkin lymphoma

References

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Fig. 1.

Simple abdominal X-ray shows mass-like lesion in the epigastric and in the left infra-phrenic area.

Fig. 2.

Contrast-enhanced coronal CT reveals diffuse thickening of the gastric wall with heterogeneous enhancement.

Fig. 3.

Gastroscopic finding. A huge well-demarcated ulcerative lesion with neighboring mucosal elevation and irregular margin is seen at the cardia.

Fig. 4.

Gastric tissue histology. (A) This slide shows lymphoid and monomorphic round cells is diffusely infiltrated within mucosa (H&E, ×400). The immunohistochemistry slides show the destructive infiltration of B-cell lineage. The tumor cells are positive for (B) CD20 (×400), (C) CD10 (×400), and (D) Bcl-6 protein (×400). (E) Total tumor cells are Ki-67 positive (×400).

Fig. 5.

Fludeoxyglucose (FDG) PET/CT. Diffuse and nodular FDG uptake in the stomach, omentum, mesentery, and pelvic dependent peritoneum.

Fig. 6.

Gastroscopic finding after three years. Normal appearance of gastric mucosa is seen at the same location (the previous lesion of cardia).

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