Journal List > Korean J Gastroenterol > v.68(2) > 1007604

Cho and Cha: Endoscopic Duodenal Snare Papillectomy Induced Complication: Prevention and Management

Abstract

Tumors of the major duodenal papilla are being recognized more often because of the increased use of diagnostic upper endoscopy and ERCP. The standard of management for ampullary tumor is local surgical excision or pancreaticoduodenectomy, but these procedures are associated with significant mortality, as well as post-operative and long-term morbidity. Endoscopic snare papillectomy was introduced as an alternative to surgery, but post-procedure complications are serious drawback. The most serious complications are perforation, delayed bleeding and pancreatitis. Identification of high risk patients, early recognition of complications, and aggressive management abates frequency and severity. Prevention and management of endoscopic duodenal papillectomy-induced complications will be reviewed in this article.

References

1. Binmoeller KF, Boaventura S, Ramsperger K, Soehendra N. Endoscopic snare excision of benign adenomas of the papilla of Vater. Gastrointest Endosc. 1993; 39:127–131.
crossref
2. Irani S, Arai A, Ayub K, et al. Papillectomy for ampullary neoplasm: results of a single referral center over a 10-year period. Gastrointest Endosc. 2009; 70:923–932.
crossref
3. Ceppa EP, Burbridge RA, Rialon KL, et al. Endoscopic versus surgical ampullectomy: an algorithm to treat disease of the ampulla of Vater. Ann Surg. 2013; 257:315–322.
4. De Palma GD. Endoscopic papillectomy: indications, techniques, and results. World J Gastroenterol. 2014; 20:1537–1543.
5. Catalano MF, Linder JD, Chak A, et al. Endoscopic management of adenoma of the major duodenal papilla. Gastrointest Endosc. 2004; 59:225–232.
crossref
6. Norton ID, Gostout CJ, Baron TH, Geller A, Petersen BT, Wiersema MJ. Safety and outcome of endoscopic snare excision of the major duodenal papilla. Gastrointest Endosc. 2002; 56:239–243.
crossref
7. Cheng CL, Sherman S, Fogel EL, et al. Endoscopic snare papillectomy for tumors of the duodenal papillae. Gastrointest Endosc. 2004; 60:757–764.
crossref
8. Zádorová Z, Dvofák M, Hajer J. Endoscopic therapy of benign tumors of the papilla of Vater. Endoscopy. 2001; 33:345–347.
crossref
9. Napoleon B, Gincul R, Ponchon T, et al. Endoscopic papillectomy for early ampullary tumors: long-term results from a large multicenter prospective study. Endoscopy. 2014; 46:127–134.
crossref
10. Ito K, Fujita N, Noda Y. Endoscopic diagnosis and treatment of ampullary neoplasm (with video). Dig Endosc. 2011; 23:113–117.
crossref
11. Cotton PB, Lehman G, Vennes J, et al. Endoscopic sphincterotomy complications and their management: an attempt at consensus. Gastrointest Endosc. 1991; 37:383–393.
crossref
12. Desilets DJ, Dy RM, Ku PM, et al. Endoscopic management of tumors of the major duodenal papilla: refined techniques to improve outcome and avoid complications. Gastrointes Endosc. 2001; 54:202–208.
crossref
13. Harewood GC, Pochron NL, Gostout CJ. Prospective, randomized, controlled trial of prophylactic pancreatic stent placement for endoscopic snare excision of the duodenal ampulla. Gastrointest Endosc. 2005; 62:367–370.
crossref
14. Han J, Lee SK, Park DH, et al. Treatment outcome after endoscopic papillectomy of tumors of the major duodenal papilla. Korean J Gastroenterol. 2005; 46:110–119.
15. Katsinelos P, Paroutoglou G, Kounturas J, et al. Safety and long-term follow-up of endoscopic snare excision of ampullary adenomas. Surg Endosc. 2006; 20:608–613.
crossref
16. Boix J, Lorenzo-Zúñiga V, Moreno de Vega V, et al. Endoscopic resection of ampullary tumors:12-year review of 21 cases. Surg Endosc. 2009; 23:45–49.
17. Yamao T, Isomoto H, Kohno S, et al. Endoscopic snare papillectomy with biliary and pancreatic stent placement for tumors of the major duodenal papilla. Surg Endosc. 2010; 24:119–124.
crossref
18. Patel R, Davitte J, Varadarajulu S, et al. Endoscopic resection of ampullary adenomas: complications and outcomes. Dig Dis Sci. 2011; 56:3235–3240.
crossref
19. Hanaro M, Ryozawa S, Iwano H, et al. Clinical impact of endoscopic papillectomy for benign-malignant borderline lesions of the major duodenal papilla. J Hepatobiliary Pancreat Sci. 2011; 18:190–194.
20. Chang WI, Min YW, Yun HS, et al. Prophylactic pancreatic stent placement for endoscopic duodenal ampullectomy: a single-center retrospective study. Gut Liver. 2014; 8:306–312.
crossref
21. Smithline A, Silverman W, Rogers D, et al. Effect of prophylactic main pancreatic duct stenting on the incidence of biliary endoscopic sphincterotomy-induced pancreatitis in high-risk patients. Gastrointest Endosc. 1993; 39:652–657.
crossref
22. Tarnasky PR, Palesch YY, Cunningham JT, Mauldin PD, Cotton PB, Hawes RH. Pancreatic stenting prevents pancreatitis after biliary sphincterotomy in patients with sphincter of Oddi dysfunction. Gastroenterology. 1998; 115:1518–1524.
crossref
23. Sofuni A, Maguchi H, Itoi T, et al. Prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis by an endoscopic pancreatic spontaneous dislodgement stent. Clin Gastroenterol Hepatol. 2007; 5:1339–1346.
crossref
24. Aizawa T, Ueno N. Stent placement in the pancreatic duct prevents pancreatitis after endoscopic sphincter dilation for removal of bile duct stones. Gastrointest Endosc. 2001; 54:209–213.
crossref
25. Moon JH, Cha SW, Cho YD, et al. Wire-guided endoscopic snare papillectomy for tumors of the major duodenal papilla. Gastrointest Endosc. 2005; 61:461–466.
crossref
26. Lee TY, Cheon YK, Shim CS, et al. Endoscopic wire-guided papillectomy versus conventional papillectomy for ampullary tumors: a prospective comparative pilot study. J Gastroenterol Hepatol. 2016; 31:897–902.
crossref
27. Akbar A, Abu Dayyeh BK, Baron TH, Wang Z, Altayar O, Murad MH. Rectal nonsteroidal anti-inflammatory drugs are superior to pancreatic duct stents in preventing pancreatitis after endoscopic retrograde cholangiopancreatography: a network metaanalysis. Clin Gastroenterol Hepatol. 2013; 11:778–783.
crossref
28. Alexander S, Bourke MJ, Williams SJ, Bailey A, Co J. EMR of large, sessile, sporadic nonampullary duodenal adenomas: technical aspects and long-term outcome (with videos). Gastrointest Endosc. 2009; 69:66–73.
crossref
29. Freeman ML. Adverse outcomes of ERCP. Gastrointest Endosc. 2002; 56:S273–S282.
crossref
30. Hussain N, Alsulaiman R, Burtin P, et al. The safety of endoscopic sphincterotomy in patients receiving antiplatelet agents: a casecontrol study. Aliment Pharmacol Ther. 2007; 25:579–584.
31. Kimchi NA, Broide E, Scapa E, Birkenfeld S. Antiplatelet therapy and the risk of bleeding induced by gastrointestinal endoscopic procedures. A systematic review of the literature and recommendations. Digestion. 2007; 75:36–45.
32. Kim MH, Moon CM, Bang SM, et al. Endoscopic papillectomy for tumors of the duodenal major papilla. Korean J Gastrointest Endosc. 2006; 32:87–93.
33. Jun DW, Choi HS. Is the endoscopic papillectomy safe procedure in periampullary tumors? Korean J Gastroenterol. 2005; 46:247–250.
34. Ito K, Fujita N, Noda Y, et al. Impact of technical modification of endoscopic papillectomy for ampullary neoplasm on the occurrence of complications. Dig Endosc. 2012; 24:30–35.
crossref
35. Park SW. Endoscopic papillectomy for ampullary lesions. Paper presented at:49th Seminar of Korean Society of Gastrointestinal Endoscopy;. 2013 Aug 25. Goyang, Korea. Seoul: Korean Society of Gastrointestinal Endoscopy, 2013. p. 112–115.
36. Moon JH. Endoscopic papillectomy for ampullary tumors. Korean J Pancreas Biliary Tract. 2007; 12:161–167.
37. Verma D, Kapadia A, Adler DG. Pure versus mixed electrosurgical current for endoscopic biliary sphincterotomy: a metaanalysis of adverse outcomes. Gastrointest Endosc. 2007; 66:283–290.
crossref
38. Guo SB, Gong AX, Leng J, Ma J, Ge LM. Application of endoscopic hemoclips for nonvariceal bleeding in the upper gastrointestinal tract. World J Gastroenterol. 2009; 15:4322–4326.
crossref
39. Bassan M, Bourke M. Endoscopic ampullectomy: a practical guide. J Interv Gastroenterol. 2012; 2:23–30.
crossref
40. Ferreira LE, Baron TH. Post-sphincterotomy bleeding: who, what, when, and how. Am J Gastroenterol. 2007; 102:2850–2858.
crossref
41. Stapfer M, Selby RR, Stain SC, et al. Management of duodenal perforation after endoscopic retrograde cholangiopancreatography and sphincterotomy. Ann Surg. 2000; 232:191–198.
crossref
42. Mutignani M, Iacopini F, Dokas S, et al. Successful endoscopic closure of a lateral duodenal perforation at ERCP with fibrin glue. Gastrointest Endosc. 2006; 63:725–727.
crossref
43. Nakagawa Y, Nagai T, Soma W, et al. Endoscopic closure of a large ERCP-related lateral duodenal perforation by using endo-loops and endoclips. Gastrointest Endosc. 2010; 72:216–217.
crossref
44. Katsinelos P, Paroutoglou G, Papaziogas B, Beltsis A, Dimiropoulos S, Atmatzidis K. Treatment of a duodenal perforation secondary to an endoscopic sphincterotomy with clips. World J Gastroenterol. 2005; 11:6232–6234.
crossref
45. Lee TH, Bang BW, Jeong JI, et al. Primary endoscopic approximation suture under cap-assisted endoscopy of an ERCP-induced duodenal perforation. World J Gastroenterol. 2010; 16:2305–2310.
crossref
46. Buffoli F, Grassia R, Iiritano E, Bianchi G, Dizioli P, Staiano T. Endoscopic “retroperitoneal fatpexy” of a large ERCP-related jejunal perforation by using a new over-the-scope clip device in Billroth II anatomy (with video). Gastrointest Endosc. 2012; 75:1115–1117.
crossref
47. Li Q, Ji J, Wang F, et al. ERCP-induced duodenal perforation successfully treated with endoscopic purse-string suture: a case report. Oncotarget. 2015; 6:17847–17850.
crossref
48. Loske G, Rucktäschel F, Schorsch T, van Ackeren V, Stark B, Müller CT. Successful endoscopic vacuum therapy with new open-pore film drainage in a case of iatrogenic duodenal perforation during ERCP. Endoscopy. 2015; 47:E577–E578.
crossref
49. Park SM. Duodenal perforation. Paper presented at:54th Seminar of Korean Society of Gastrointestinal Endoscopy;. 2016 Mar 20. Goyang, Korea. Seoul: Korean Society of Gastrointestinal Endoscopy, 2016. p. 201–206.

Table 1.
Post Papillectomy Complications10
Complication Rate (%)
Perforation 0–8
Bleeding 2–30
Pancreatitis 3–25
Cholangitis 0–5
Papillary stenosis in follow-up 0–8
Table 2.
Effect of Pancreatic Stenting on Acute Pancreatitis after Endoscopic Papillectomy in Reported Series
First author Patient (n) Routine pancreatic stent Stent patients Papillectomy induced pancreatitis
Total (%) Stent group Non-stent group p-value
Binmoeller1 25 No 1 (4) 12 1/1 (100) 2/24 (8) NR
Desilets12 13 Yes 11 (85) 8 0/11 (0) 1/2 (50) NR
Norton6 26 No 10 (4) 15 2/10 (20) 2/16 (13) 0.5 (NS)
Cheng7 55 No 41 (75) 9 4/41 (10) 1/4 (25) 0.33 (NS)
Catalano5 103 Yes 91 (88) 5 3/91 (3) 2/12 (17) 0.1 (NS)
Harewood13 19 RCT 10 (91) 16 1/11 (9) 2/8 (25) 0.3 (NS)
Han14 22 No 11 (50) 0 0/11 (0) 0/11 (0) NS
Katsinelos15 14 No 4 (29) 7 0/4 (0) 1/10 (10) NR
Irani2 102 Yes 94 (92) 10 9/94 (10) 1/8 (13) NR
Boix16 21 No 0 19 0/0 (0) 4/21 (19) NR
Yamao17 36 Yes 35 (97) 8 2/35 (6) 1/1 (100) NR
Patel18 38 No 20 (53) 8 1/20 (5) 2/18 (11) 0.62 (NS)
Hanaro19 28 Yes 23 (82) 7 0/23 (0) 2/5 (40) NR
Chang20 82 No 54 (66) 9 6/54 (11) 2/28 (7) NR

Values are presented as n only, n (%), or % only.

RCT, randomized controlled trial; NR, not reported.

TOOLS
Similar articles