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Abstract
Amyloidosis is a rare disease defined by extracellular deposits of amorphous fibrillar proteins, derived from aggregations of misfolded proteins. Localization of amyloidosis in the gallbladder is uncommon; only eight cases have been reported. We describe a case of amyloidosis diagnosed by cholecystectomy, which possibly also affected the liver and kidney. The patient was misdiagnosed with polymyalgia rheumatica, but after a cholecystectomy to treat chronic cholecystitis, we ultimately diagnosed him with amyloidosis. We review amyloidosis with gallbladder involvement in the literature.
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Fig. 1.
Chest CT showed gallbladder (GB) wall thickening at the fundus, suggesting chronic cholecystitis, GB cancer, or adenomyomatosis.
Fig. 2.
Abdominal ultrasound showed diffuse mild gallbladder (GB) wall thickening, suggesting chronic cholecystitis with no definite visible mass in the GB.
Fig. 3.
(A) Postoperative H&E staining of the gallbladder showed chronic cholecystitis with amorphous eosinophilic depositions in the lamina propria mucosa (×40). (B) In Congo red staining of the gallbladder, amyloid depositions were stained in the lamina propria mucosa (×40).
Fig. 4.
Apple-green birefringence was demonstrated in polarized light microscopy of Congo red staining (×40).
Table 1.
Cases with Gallbladder Localization of Amyloidosis in the Literature
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