The Influence of Proton Pump Inhibitor Use on the Gut Microbiome

Chan Hyuk Park; Sang Kil Lee

doi:10.4166/kjg.2016.68.5.288

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Park and Lee: The Influence of Proton Pump Inhibitor Use on the Gut Microbiome

Research Update

Korean J Gastroenterol 2016;68(5):288-290.

Published online: 4 October 2016

DOI: https://doi.org/10.4166/kjg.2016.68.5.288

The Influence of Proton Pump Inhibitor Use on the Gut Microbiome

Chan Hyuk Park, Sang Kil Lee¹

Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea

¹Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Correspondence to: Sang Kil Lee, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea. Tel: +82-2-2228-1996, Fax: +82-2-393-6884, E-mail: sklee@yuhs.ac

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Proton Pump Inhibitors Affect the Gut Microbiome

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References

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8. Washio E, Esaki M, Maehata Y, et al. Proton pump inhibitors increase incidence of nonsteroidal anti-inflammatory drug-induced small bowel injury: a randomized, placebo-controlled trial. Clin Gastroenterol Hepatol. 2016; 14:809–815.e1.

9. Blackler RW, Gemici B, Manko A, Wallace JL. NSAID-gastro- enteropathy: new aspects of pathogenesis and prevention. Curr Opin Pharmacol. 2014; 19:11–16.

10. Wallace JL, Syer S, Denou E, et al. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology. 2011; 141:1314–1322. 1322.e1–5.

11. McDonald EG, Milligan J, Frenette C, Lee TC. Continuous proton pump inhibitor therapy and the associated risk of recurrent Clostridium difficile infection. JAMA Intern Med. 2015; 175:784–791.

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