Journal List > Korean J Gastroenterol > v.68(5) > 1007578

Noh, Hong, Han, Park, Lee, Lee, Ko, Lee, and Lee: Eradication Rate by Duration of Third-line Rescue Therapy with Levofloxacin after Helicobacter pylori Treatment Failure in Clinical Practice

Abstract

Background/Aims

This study evaluated the eradication rate of levofloxacin-containing rescue therapy by treatment duration in patients in whom previous first- and second-line treatment failed.

Methods

Fifty-five patients with persistent Helicobacter pylori infection after first-line therapy and second-line therapy were studied in a single referral academic center. We compared the eradication rates by the treatment duration of third-line therapy.

Results

Of 55 patients, 12 (21.8%) received rescue therapy for seven days, 24 (43.6%) received rescue therapy for 10 days, and 19 (34.5%) received rescue therapy for 14 days. The eradication rates of therapy with levofloxacin were 65.5% in the 55 enrolled patients and 73.5% in the 49 patients who underwent follow-up testing. In cases where follow-up testing was performed, the eradication rate of 7-day therapy was 58.3%, of 10-day 68.2%, and of 14-day therapy 93.3%. Eradication rate of 14-day therapy was higher than 7-day (p=0.06) and 10-day (p=0.108), but chance could not be ruled out in the difference among groups.

Conclusions

This study showed somewhat increasing of H. pylori eradication rate by extending the duration of levofloxacin-containing rescue therapy to 14 days.

References

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Fig. 1.
Study flowchart.
kjg-68-260f1.tif
Table 1.
Baseline Characteristics of Enrolled Patients
Characteristic Total (n=55) 7-day group (n=12) 10-day group (n=24) 14-day group (n=19) p-value
Age (yr) 57.4±12.1 54.8±13.7 59.3±12.4 56.7±10.9 NS*
Sex, male/female 27 (49.1)/28 (50.9) 5 (41.7)/7 (58.3) 12 (50.0)/12 (50.0) 10 (52.6)/9 (47.4) 0.884
Disease         0.231
 Gastric ulcer 38 (69.1) 7 (58.3) 19 (79.2) 12 (63.2)  
 Duodenal ulcer 16 (29.1) 4 (33.3) 5 (20.8) 7 (36.8)  
Helicobacter pylori gastritis 1 (1.8) 1 (8.3) 0 (0) 0 (0)  
Follow-up 49 (89.1) 12 (100) 22 (91.7) 15 (78.9) 0.151

Values are presented as mean±SD or n (%).

* No significant differences between groups (p>0.05).

Table 2.
Eradication Rate according to Duration of Third-line Rescue Treatment
Treatment duration Eradication rate
Enrolled patients (total, n=55) Subgroup (follow-up, n=49)
7-day group 58.3 (0.286–0.835) 58.3 (0.286–0.835)
10-day group 62.5 (0.408–0.805) 68.2 (0.451–0.853)
14-day group 73.7 (0.486–0.899) 93.3 (0.660–0.997)
Total 65.5 (0.513–0.774) 73.5 (0.587–0.846)

Values are presented as % (95% CI).

p=0.447 compared with 7-day group, 7-day group.

p=0.06 compared with

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