Current Status of Translational Research on Constipation

Hyun Jik Lee; Kyung Sik Park

doi:10.4166/kjg.2016.68.3.143

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Lee and Park: Current Status of Translational Research on Constipation

Review Article

Korean J Gastroenterol 2016;68(3):143-147.

Published online: 4 October 2016

DOI: https://doi.org/10.4166/kjg.2016.68.3.143

Current Status of Translational Research on Constipation

Hyun Jik Lee, Kyung Sik Park

Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea

Correspondence to: Kyung Sik Park, Department of Internal Medicine, Keimyung University Dongsan Medical Center, 56 Dalseong-ro, Jung-gu, Daegu 41931, Korea. Tel: +82-53-250-7088, Fax: +82-53-250-7442, E-mail: seenae99@dsmc.or.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Constipation is one of the most common gastrointestinal disorders with a prevalence up to 16.5% in the general population. It is frequently multifactorial and the pathophysiologic mechanism of constipation is not fully understood. Many preclinical studies of constipation have used animal models. Translational research using these animal models is essential to the investigation of neurogenic and myogenic mechanisms of colon, and to the estimation of the clinical efficacy of new drugs. In this review, we discuss some of the current translational research projects on constipation using animal models.

Keywords: Constipation, Translational medical research, Gastrointestinal motility, Colon

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