Current Status of Translational Research on Irritable Bowel Syndrome

Yong Hwan Kwon; Hyun Jin Kim

doi:10.4166/kjg.2016.68.3.138

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Kwon and Kim: Current Status of Translational Research on Irritable Bowel Syndrome

Review Article

Korean J Gastroenterol 2016;68(3):138-142.

Published online: 4 October 2016

DOI: https://doi.org/10.4166/kjg.2016.68.3.138

Current Status of Translational Research on Irritable Bowel Syndrome

Yong Hwan Kwon, Hyun Jin Kim¹

Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea

¹Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea

Correspondence to: Hyun Jin Kim, Department of Internal Medicine, Gyeongsang National University School of Medicine, 15 Jinju-daero 816beon-gil, Jinju 52727, Korea. Tel: +82-55-750-8820, Fax: +82-55-758-9122, E-mail: imdrkim@naver.com

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. The pathophysiology of IBS is not completely understood. Genetic, immune, environmental, inflammatory, neurological and psychological factors contribute to the risk of this condition. Traditional research explored gastrointestinal motor abnormalities, central neural dysregulation, abnormal psychological features, and visceral hypersensitivity. More recent investigations consider bacterial overgrowth, abnormal serotonin pathways, altered gut flora, immune activation and mucosal inflammation. The purpose of this article is to review recent translational research concerning the pathophysiology, biomarker and genetic factors of IBS and to encourage IBS research in Korea.

Keywords: Irritable bowel syndrome, Translational medical research, Biomarkers, Genetic, Physiopathology

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