Journal List > Korean J Gastroenterol > v.68(3) > 1007550

This article has been corrected. See "Corrigendum: Current Status of Translational Research on Functional Dyspepsia" in Volume 68 on page 291.
Park, Kim, Park, Shin, and Jung: Current Status of Translational Research on Functional Dyspepsia

Abstract

Functional dyspepsia (FD) has a diverse pathophysiology and treatment is difficult. Translational research to understand its pathophysiology is underway. Hormonal factors, including ghrelin, seem promising, offering an understanding of appetite and eating. Functional MRI brain study can expand our knowledge of the brain-gut axis. Finally, immune systems research, including mast cells, can help with comprehensive understanding of FD. The clinical approaches based on these translational research projects are necessary to improve understanding of FD, leading to more effective treatment.

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Table 1.
Brain Imaging Data in Functional Dyspepsia (FD) Literature
  FD vs. HC FD subgroups
Resting Sham distension Others Resting Distension> baseline
SI/SII 35,41 45      
  Interhemi FC ↑37        
PFC 35,38,41 45 Acupuncture ↓48 Abused ↑46 Non-abused ↑4
  Interhemi FC ↑37     Severe ↑35  
        AD ↑36  
OFC 35,41 45 Acupuncture ↓48  
  34,38        
Insula 35,38,41 45 Acupuncture ↓48 Severe ↑35  
  Interhemi FC ↑37     AD ↑36  
ACC 35,38,41   Acupuncture ↓48 Severe ↑5  
  2        
  Interhemi FC ↑37        
  FC with insula, PFC ↓40        
Thalamus 35,38,41     Severe ↑35  
  Interhemi FC ↑37     AD ↑36  
  PFC ↑40        
  FC with insula, PFC ↓40        
Hippo/amygdala 41     Non-abused ↑46 Abused ↑46

HC, healthy controls; sham, sham distention; SI (II), primary (secondary) somatosensory cortex; FC, functional connectivity; PFC, prefrontal cortex; AD, anxiety and depression; OFC, orbitofrontal cortex; ACC, anterior cingulate cortex; Hippo, hippocampus; Interhemi, interhemispheric.

↑, greater than healthy controls; ↓, lower than healthy controls.

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