Current Status of Translational Research on Gastroesophageal Reflux Disease

In Du Jeong; Moo In Park

doi:10.4166/kjg.2016.68.3.127

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Jeong and Park: Current Status of Translational Research on Gastroesophageal Reflux Disease

Review Article

Korean J Gastroenterol 2016;68(3):127-131.

Published online: 4 October 2016

DOI: https://doi.org/10.4166/kjg.2016.68.3.127

Current Status of Translational Research on Gastroesophageal Reflux Disease

In Du Jeong, Moo In Park¹

Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea

¹Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea

Correspondence to: Moo In Park, Department of Internal Medicine, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 49267, Korea. Tel: +82-51-990-6719, Fax: +82-51-990-5055, E-mail: mipark@kosinmed.or.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The prevalence of gastroesophageal reflux disease (GERD) and the incidence of some of its complications have risen strikingly over the last few decades. With the increase in our understanding of the pathophysiology of GERD along with the development of proton pump inhibitors, the diagnostic and therapeutic approaches to GERD have changed dramatically over the past decade. However, GERD still poses a problem to many clinicians since the spectrum of the disease has evolved to encompass more challenging presentations such as refractory GERD and extraesophageal manifestations. The aim of this article is to provide a review of available current translational research on GERD. This review includes acid pocket, ambulatory pH monitoring, impedance pH monitoring, mucosa impedance, and high resolution manometry. This article discusses current translational research on GERD.

Keywords: Gastroesophageal reflux, Esophageal pH monitoring, Impedance

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